...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Loss of ARID1A, ARID1B, and ARID2 Expression During Progression of Gastric Cancer
【24h】

Loss of ARID1A, ARID1B, and ARID2 Expression During Progression of Gastric Cancer

机译：胃癌进展过程中ARID1A，ARID1B和ARID2表达的丧失

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aim: Gastric cancer is a common cancer worldwide. Chromatin remodeling complexes have emerged as tumor suppressors and include AT-rich interaction domain-containing proteins (ARIDs) 1A, 1B, and 2. We examined their expression and clarified their roles in gastric carcinogenesis. Materials and Methods: The expression of ARIDs was studied by immunohistochemistry in 469 gastric carcinoma and 47 adenoma samples and was analyzed according to clinicopathological factors. Results: Low expression rates of ARID1A, 1B, and 2 in gastric carcinoma were 20%, 10%, and 15% respectively. ARIDs are correlated to each other. Low expression of ARID1A was related to advanced tumor and vessel infiltration. Loss of ARID1B and ARID2 was also related to tumor progression, but their relationship was weaker than that of ARID1A. Conclusion: ARID1A is the strongest tumor suppressor in gastric carcinogenesis among ARIDs. Their aberration might be caused by shared mechanisms such as mutation and methylation.
机译：背景/目的：胃癌是世界范围内的常见癌症。染色质重塑复合物已成为肿瘤抑制因子，包括富含AT相互作用域的蛋白（ARID）1A，1B和2。我们检查了它们的表达并阐明了它们在胃癌发生中的作用。材料与方法：采用免疫组织化学方法对469例胃癌和47例腺瘤样品中ARIDs的表达进行分析，并根据临床病理因素进行分析。结果：ARID1A，1B和2在胃癌中的低表达率分别为20％，10％和15％。 ARID相互关联。 ARID1A的低表达与晚期肿瘤和血管浸润有关。 ARID1B和ARID2的丢失也与肿瘤的进展有关，但它们的关系比ARID1A弱。结论：ARID1A是ARID中胃癌发生最强的肿瘤抑制因子。它们的畸变可能是由突变和甲基化等共同机制引起的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号