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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Pressurized Intraperitoneal Aerosol Chemotherapy with Cisplatin and Doxorubicin in Women with Peritoneal Carcinomatosis: A Cohort Study
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Pressurized Intraperitoneal Aerosol Chemotherapy with Cisplatin and Doxorubicin in Women with Peritoneal Carcinomatosis: A Cohort Study

机译：腹膜癌气肿妇女的顺铂和阿霉素加压腹膜内气雾剂化学疗法：一项队列研究

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Aim: We aimed to assess the objective tumor response (OTR) to laparoscopic pressurized intraperitoneal aerosol chemotherapy (PIPAC) in women with peritoneal carcinomatosis (PC). Patients and Methods: We carried-out a retrospective cohort study of women with PC undergoing repeated courses of PIPAC with 7.5 mg/m(2) of cisplatin and 1.5 mg/m(2) of doxorubicin. OTR was defined as histological regression. Peritoneal carcinomatosis index (PCI) improvement on video-laparoscopy and ascites volume reduction were secondary outcomes. Quality of life was assessed by the European Organization for Research & Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-30+3. Results: A total of 252 PIPACs were performed in 99 women with PC and ovarian (n=84), primary peritoneal (n=6), cervical (n=3), endometrial (n=3), fallopian tube (n=1), and breast (n=1) cancer and pseudomyxoma peritonei (n=1). Laparoscopic non-access rate was 17% (17/99). Fifty women had more than one PIPAC procedures, with an OTR of 76% (38/50) and PCI improvement in 64% (32/50). Ascites volume significantly decreased from 762 +/- 1170 ml to 167 +/- 456 ml (p=0.02). A high initial Karnofsky Index was correlated with receiving more than one PIPAC (p<0.0001) and a high number of previous surgeries with laparoscopic non-access (p=0.01). Twenty adverse events of Common Terminology Criteria for Adverse Events grade 3 or more were noted. Absence of ascites (odds ratio=8.45, 95% confidence interval=1.9-3.6; p<0.0001), but not patient age, serum cancer antigen-125, and Karnofsky Index independently predicted OTR. EORTC QLQ-30+3 scores for global physical health, nausea/vomiting, appetite loss, and constipation improved during therapy. Conclusion: PIPAC with cisplatin and doxorubicin is an active treatment in women with PC and preserves quality of life. Appropriate patient selection regarding performance status and the number of prior surgeries is important.
机译：目的：我们旨在评估腹膜癌（PC）妇女对腹腔镜加压腹膜内气雾化学疗法（PIPAC）的客观肿瘤反应（OTR）。患者和方法：我们对PC的妇女进行了一项回顾性队列研究，他们接受了7.5 mg / m（2）的顺铂和1.5 mg / m（2）的阿霉素重复进行PIPAC治疗。 OTR被定义为组织学回归。腹腔镜下腹膜癌变指数（PCI）的改善和腹水量的减少是次要结果。生活质量由欧洲癌症生活质量研究与治疗组织（EORTC QLQ）-30 + 3进行评估。结果：对99例PC和卵巢（n = 84），原发性腹膜（n = 6），宫颈（n = 3），子宫内膜（n = 3），输卵管（n = 1）的女性共进行了252次PIPAC。 ），乳腺癌（n = 1）和腹膜假粘液瘤（n = 1）。腹腔镜手术的非接触率为17％（17/99）。 50名妇女接受了不止一次PIPAC手术，OTR率为76％（38/50），PCI改善率为64％（32/50）。腹水量从762 +/- 1170毫升降至167 +/- 456毫升（p = 0.02）。较高的初始Karnofsky指数与接受不止一个PIPAC（p <0.0001）和先前接受腹腔镜手术的大量手术相关（p = 0.01）。记录到20个3级或以上不良事件通用术语标准的不良事件。没有腹水（赔率= 8.45，95％置信区间= 1.9-3.6; p <0.0001），但没有患者年龄，血清癌抗原-125和卡诺夫斯基指数独立预测OTR。治疗期间，EORTC QLQ-30 + 3在整体身体健康，恶心/呕吐，食欲不振和便秘方面得分得到改善。结论：顺铂和阿霉素的PIPAC是一种有效的治疗PC机女性的方法，可保持生活质量。关于表现状态和先前手术数量的适当患者选择很重要。

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