Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model

Jarod C. Finlay; Thomas H. Foster

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Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model

机译：用前向伴随模型恢复血红蛋白氧饱和度和固有荧光

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We present two forward-adjoint models for recovering intrinsic fluorescence spectra and hemoglobin oxygen saturation of turbid samples. The first fits measured diffuse reflectance spectra to obtain the absorption and scattering spectra of the medium, and these are then used to correct distortions imposed on the fluorescence spectrum by absorption and scattering. The second fits only the measured fluorescence spectrum to determine simultaneously the amplitudes of absorption and fluorescence basis spectra and scattering parameters. Both methods are validated with Monte Carlo simulations and experimentally in scattering phantoms containing nicotinamide adenine dinucleotide and human erythrocytes. Preliminary measurements from murine tumors in vivo are presented.

机译：我们提出了两个正向伴随模型，用于恢复浑浊样品的固有荧光光谱和血红蛋白氧饱和度。首先拟合测量的漫反射光谱以获得介质的吸收和散射光谱，然后将它们用于校正由于吸收和散射而施加在荧光光谱上的畸变。第二个仅拟合测量的荧光光谱，以同时确定吸收光谱和荧光基础光谱的振幅以及散射参数。两种方法均已通过Monte Carlo模拟验证，并在散射包含烟酰胺腺嘌呤二核苷酸和人类红细胞的模型中进行了实验验证。提出了从小鼠体内肿瘤的初步测量。

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《Applied optics》 |2005年第10期|共17页
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Jarod C. Finlay; Thomas H. Foster;
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1. Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model [J] . Jarod C. Finlay, Thomas H. Foster Applied Optics . 2005,第10期

机译：使用前向伴随模型恢复血红蛋白氧饱和度和固有荧光
2. A Novel Oxygen-Hemoglobin Model for Non-Contact Sleep Monitoring of Oxygen Saturation [J] . Tran Vinh Phuc, Al-Jumaily Adel Ali IEEE sensors journal . 2019,第24期

机译：一种新型氧血红蛋白模型，用于氧饱和度的非接触式睡眠监测
3. Dynamic model for the tissue concentration and oxygen saturation of hemoglobin in relation to blood volume, flow velocity, and oxygen consumption: Implications for functional neuroimaging and coherent hemodynamics spectroscopy (CHS) [J] . Sergio Fantini NeuroImage . 2014,第1期

机译：与血容量，流速和耗氧量相关的血红蛋白组织浓度和血氧饱和度的动态模型：对功能性神经影像学和相干血流动力学光谱学（CHS）的影响
4. Simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in humans and other animal models using a single light source [C] . Paul Dent, Sai Han Tun, Seth Fillioe, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI . 2018

机译：使用单个光源对人和其他动物模型中的血细胞比容，血管体积，血红蛋白氧饱和度，脉搏率和呼吸率进行同时，无创，体内连续监测
5. Dual-spectral endoscopic near-infrared optical tomography for assessment of hemoglobin concentration and oxygen saturation. [D] . Xie, Hao. 2008

机译：双光谱内窥镜近红外光学层析成像技术可评估血红蛋白浓度和血氧饱和度。
6. Dynamic model for the tissue concentration and oxygen saturation of hemoglobin in relation to blood volume flow velocity and oxygen consumption: Implications for functional neuroimaging and coherent hemodynamics spectroscopy (CHS) [O] . Sergio Fantini -1

机译：与血容量流速和耗氧量相关的血红蛋白组织浓度和血氧饱和度的动态模型：对功能性神经影像学和相干血流动力学光谱学（CHS）的影响
7. Experimental recovery of intrinsic fluorescence and fluorophore concentration in the presence of hemoglobin: spectral effect of scattering and absorption on fluorescence [O] . Vinh Nguyen Du Le, Michael S. Patterson, Thomas J. Farrell, 2015

机译：血红蛋白存在下固有荧光和荧光团浓度的实验恢复：散射和吸收对荧光的光谱效应
8. Effects of P-aminopropiophenone (PAPP), P-aminoheptanoylphenone (PAHP), and P-aminooctanoylphenone (PAOP) Exposure on Methemoglobin, Sulfhemoglobin, Oxyhemoglobin, Oxygen Content, Reduced Hemoglobin, Oxygen Saturation, Carboxyhemoglobin, and Oxygen Capaci [R] . Rockwood, G. A., Bakin, S. I., Romano, J. A., 1996

机译：p-氨基苯丙酮（papp），p-氨基庚酰苯酮（paHp）和p-氨基辛酰苯酮（paOp）暴露对高铁血红蛋白，硫化血红蛋白，氧合血红蛋白，氧含量，血红蛋白减少，氧饱和度，碳氧血红蛋白和氧气电容的影响

Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model

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