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首页> 外文期刊>Applied optics >Design, assembly, and optical bench testing of a high-numerical-aperture miniature injection-molded objective for fiber-optic confocal reflectance microscopy
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Design, assembly, and optical bench testing of a high-numerical-aperture miniature injection-molded objective for fiber-optic confocal reflectance microscopy

机译：用于光纤共焦反射显微镜的高数值孔径微型注塑物镜的设计，组装和光学测试

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摘要

The design, analysis, assembly methods, and optical-bench test results for a miniature injection-molded plastic objective lens used in a fiber-optic confocal reflectance microscope are presented. The five-lens plastic objective was tested as a stand-alone optical system before its integration into a confocal microscope for in vivo imaging of cells and tissue. Changing the spacing and rotation of the individual optical elements can compensate for fabrication inaccuracies and improve performance. The system performance of the miniature objective lens is measured by use of an industry-accepted slanted-edge modulation transfer function (MTF) metric. An estimated Strehl ratio of 0.61 and a MTF value of 0.66 at the fiber-optic bundle Nyquist frequency have been obtained. The optical bench testing system is configured to permit interactive optical alignment during testing to optimize performance. These results are part of an effort to demonstrate the manufacturability of low-cost, high-performance biomedical optics for high-resolution in vivo imaging. Disposable endoscopic microscope objectives could help in vivo confocal microscopy technology mature to permit wide-scale clinical screening and detection of early cancers and precancerous lesions.
机译：介绍了用于光纤共聚焦反射显微镜的微型注塑塑料物镜的设计，分析，组装方法和光学平台测试结果。在将其集成到共聚焦显微镜中以对细胞和组织进行体内成像之前，将五透镜塑料物镜作为独立的光学系统进行了测试。改变各个光学元件的间距和旋转度可以补偿制造误差并提高性能。微型物镜的系统性能通过使用行业认可的斜边调制传递函数（MTF）度量来测量。在光纤束奈奎斯特频率下，估计的斯特列尔比为0.61，MTF值为0.66。光学平台测试系统配置为允许在测试过程中进行交互式光学对准，以优化性能。这些结果是努力证明低成本，高性能生物医学光学器件可用于高分辨率体内成像的一部分。一次性内窥镜显微镜物镜可以帮助体内共聚焦显微镜技术成熟，从而可以对早期癌症和癌前病变进行大规模临床筛查和检测。

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