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Determination of optical probe interrogation field of near-infrared reflectance: phantom and Monte Carlo study

机译:确定近红外反射率的光学探针询问场:幻影和蒙特卡罗研究

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An optical probe used to localize human brain tissues in vivo has been reported previously. It was ableto sense the underlying tissue structure with an optical interrogation field, termed as "look ahead distance" (LAD). A new side-firing probe has been designed with its optical window along its side. We have defined the optical interrogation field of the new side probe as "look aside distance" (LASD). The purpose of this study is to understand the dependence of the LAD and LASD on the optical properties of tissue, the light source intensity, and the integration time of the detector, using experimental and computational methods. The results show that a decrease in light intensity does decrease the LAD and LASD and that an increase in integration time of detection may not necessarily improve the depths of LAD and LASD. Furthermore, Monte Carlo simulation results suggest that the LAD/LASD decreases with an increase in reduced scattering coefficient to a point, after which the LAD/LASD remains constant. We expect that an optical interrogation field of a tip or side probe is approximately 1-2 mm in white matter and 2-3.5 mm in gray matter. These conclusions will help us optimally manipulate the parameter settings during surgery and determine the spatial resolution of the probe.
机译:先前已经报道了用于在体内定位人脑组织的光学探针。它能够通过光学询问场来感知下面的组织结构,该询问场被称为“向前看距离”(LAD)。设计了一种新的侧面发射探头,其光学窗口沿侧面。我们将新的侧面探头的光学询问场定义为“视线距离”(LASD)。这项研究的目的是通过实验和计算方法,了解LAD和LASD对组织光学特性,光源强度和检测器积分时间的依赖性。结果表明,光强度的降低的确会降低LAD和LASD,并且检测积分时间的增加不一定能改善LAD和LASD的深度。此外,蒙特卡洛模拟结果表明,LAD / LASD随散射系数的减小而减小,直至达到一定程度,此后LAD / LASD保持恒定。我们期望尖端或侧面探针的光学询问场在白质中约为1-2 mm,在灰质中约为2-3.5 mm。这些结论将有助于我们在手术期间最佳地控制参数设置并确定探头的空间分辨率。

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