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首页> 外文期刊>Applied optics >In vivo assessment of wall strain in embryonic chick heart by spectral domain optical coherence tomography
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In vivo assessment of wall strain in embryonic chick heart by spectral domain optical coherence tomography

机译：光谱域光学相干断层扫描在体内评估胚胎鸡心中的壁张力

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The ability to measure in vivo wall strain in embryonic hearts is important for fully understanding the mechanisms of cardiac development. Optical coherence tomography (OCT) is a powerful tool for the three-dimensional imaging of complex myocardial activities in early-stage embryonic hearts with high spatial and temporal resolutions. We describe a method to analyze periodic deformations of myocardial walls and evaluate in vivo myocardial wall strains with a high-speed spectral domain OCT system. We perform four-dimensional scanning on the outflow tract (OFT) of chick embryonic hearts and determine a special cross-section in which the OFT can be approximated as an annulus by analyzing Doppler blood-flow velocities. For each image acquired at the special cross-section, the annular myocardial wall is segmented with a semiautomatic boundary-detection algorithm, and the fluctuation myocardial wall thickness is calculated from the area and mean circumference of the myocardial wall. The experimental results shown with the embryonic chick hearts demonstrate that the proposed method is a useful tool for studying the biomechanical characteristics of embryonic hearts. (C) 2015 Optical Society of America
机译：测量胚胎心脏的体内壁应变的能力对于充分了解心脏发育的机制很重要。光学相干断层扫描（OCT）是在早期胚胎心脏中以高时空分辨率对复杂心肌活动进行三维成像的强大工具。我们描述了一种方法，用于分析心肌壁的周期性变形并通过高速频谱域OCT系统评估体内心肌壁应变。我们对雏鸡胚胎心脏的流出道（OFT）进行三维扫描，并通过分析多普勒血流速度确定一个特殊的横截面，在该横截面中，OFT可以近似为环面。对于在特殊横截面处获取的每个图像，使用半自动边界检测算法对环形心肌壁进行分割，并根据心肌壁的面积和平均周长计算出心肌壁的起伏厚度。胚胎小鸡心脏显示的实验结果表明，该方法是研究胚胎心脏生物力学特性的有用工具。 （C）2015年美国眼镜学会

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