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首页> 外文期刊>European Journal of Pharmacology: An International Journal >Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease
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Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease

机译：芒果苷对阿尔茨海默病治疗中脑胆碱酯酶和脑生物胺的神经药理作用

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摘要

The present study was conducted to evaluate the neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines along with its antioxidant status. Scopolamine and natural aging were employed as an experimental amnesia inducing agents. The tested dose of Mangiferin (40, 20 and 10 mg/kg) significantly improved the learning ability and retention of learned memory in Elevated plus Maze and Passive Shock Avoidance exteroceptive behavioural models. Pre-treatment with Mangiferin restored increased whole brain acetylcholinestrease, lipid peroxidation and reduced glutathione due to scopolamine and natural aging. Whole brain increased dopamine and nor-adrenaline content in brain in the inducing groups were reversed by tested doses of Mangiferin insignificantly. Moreover the cerebroprotective effect of Mangiferin was well supported by photomicrographs of Hippocampus of brain, where as severity of cell damage, number of pyknotic black neurons, formation of karyorrhexis, karyolysis and number of neuronal cell death were less comparative to scopolamine group. The observed effects of Mangiferin claim that it would be worthwhile to utilize in the treatment of Alzheimer's disease.
机译：本研究旨在评估芒果苷对脑胆碱酯酶和脑生物胺的神经药理作用及其抗氧化状态。 co草胺和自然衰老被用作实验性健忘症诱导剂。 Mangiferin的测试剂量（40、20和10 mg / kg）显着提高了在高加迷宫和被动避避触觉行为模型中的学习能力和学习记忆的保持能力。芒果苷预处理可恢复东brain碱和自然衰老引起的全脑乙酰胆碱酯酶增加，脂质过氧化和减少谷胱甘肽。诱导剂量组的全脑增加的多巴胺和去甲肾上腺素含量在被试验剂量的芒果苷中可被逆转。此外，脑海马显微照片很好地支持了芒果苷的脑保护作用，与东pol碱组相比，由于细胞损伤的严重程度，致死性黑色神经元的数量，角膜溢血的形成，溶核作用和神经元细胞死亡的数量较少。芒果苷的观察到的作用声称，将其用于治疗阿尔茨海默氏病是值得的。

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