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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >HIGH-FREQUENCY STIMULATION OF THE HIPPOCAMPUS PROTECTS AGAINST SEIZURE ACTIVITY AND HIPPOCAMPAL NEURONAL APOPTOSIS INDUCED BY KAINIC ACID ADMINISTRATION IN MACAQUES
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HIGH-FREQUENCY STIMULATION OF THE HIPPOCAMPUS PROTECTS AGAINST SEIZURE ACTIVITY AND HIPPOCAMPAL NEURONAL APOPTOSIS INDUCED BY KAINIC ACID ADMINISTRATION IN MACAQUES

机译：猕猴海藻酸诱导的癫痫发作抵抗海马神经元凋亡和海马神经元凋亡的高频刺激。

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摘要

Kainic acid (KA) administration is known to cause seizures and neuronal death in the hippocampus. High-frequency stimulation (HFS) of the hippocampus can be a promising method in the treatment of epilepsy while the mechanism of action is unknown yet. It remains unknown whether HFS is neuroprotective for hippocampal neurons following KA-induced seizures in macaques, although HFS has neuroprotective effects in animal models of Parkinson's disease. We therefore examined the effects of HFS on KA-induced seizures and neuronal survival in macaque's hippocampus. Seizure frequency following KA that led to seizures in macaques was strongly reduced by HFS of the hippocampus. In addition, administration of KA led to marked neuronal apoptosis in the hippocampus, accompanied by increased levels of Bax, activated caspase-3 and decreased levels of Bcl-2. HFS was found to attenuate changes in apoptosis-related proteins and robustly decreased neuronal loss following KA administration. These data indicate that hippocampal HFS can protect hippocampal neurons against KA neurotoxicity, and that HFS neuroprotection is likely to operate with inhibition of apoptosis.
机译：已知使用海藻酸（KA）会导致海马癫痫发作和神经元死亡。海马高频刺激（HFS）可能是治疗癫痫的一种有前途的方法，但其作用机理尚不清楚。尽管HFS在帕金森氏病的动物模型中具有神经保护作用，但目前尚不清楚HFS是否对KA诱导的猕猴癫痫发作后的海马神经元具有神经保护作用。因此，我们检查了HFS对猕猴海马中KA诱发的癫痫发作和神经元存活的影响。海马的HFS大大降低了KA后导致猕猴癫痫发作的发作频率。另外，KA的施用导致海马中明显的神经元凋亡，伴随着Bax水平升高，激活的caspase-3水平降低和Bcl-2水平降低。发现在给予KA后，HFS可以减弱凋亡相关蛋白的变化，并强烈减少神经元的损失。这些数据表明，海马HFS可以保护海马神经元免受KA神经毒性，并且HFS神经保护作用可能与抑制细胞凋亡有关。

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