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首页> 外文期刊>The Journal of Chemical Physics >Polymer capture by electro-osmotic flow of oppositely charged nanopores
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Polymer capture by electro-osmotic flow of oppositely charged nanopores

机译：带有相反电荷的纳米孔的电渗流捕获聚合物

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The authors have addressed theoretically the hydrodynamic effect on the translocation of DNA through nanopores. They consider the cases of nanopore surface charge being opposite to the charge of the translocating polymer. The authors show that, because of the high electric field across the nanopore in DNA translocation experiments, electro-osmotic flow is able to create an absorbing region comparable to the size of the polymer around the nanopore. Within this capturing region, the velocity gradient of the fluid flow is high enough for the polymer to undergo coil-stretch transition. The stretched conformation reduces the entropic barrier of translocation. The diffusion limited translocation rate is found to be proportional to the applied voltage. In the authors' theory, many experimental variables (electric field, surface potential, pore radius, dielectric constant, temperature, and salt concentration) appear through a single universal parameter. They have made quantitative predictions on the size of the adsorption region near the pore for the polymer and on the rate of translocation. (c) 2007 American Institute of Physics.
机译：作者从理论上解决了水动力作用对DNA通过纳米孔的转运的影响。他们考虑了纳米孔表面电荷与易位聚合物电荷相反的情况。作者表明，由于在DNA易位实验中跨纳米孔的高电场，电渗流能够产生与纳米孔周围聚合物大小相当的吸收区域。在该捕获区域内，流体流动的速度梯度足够高，以使聚合物经历线圈-拉伸转变。拉伸的构象减少了熵转运的障碍。发现扩散受限的移位率与施加的电压成比例。在作者的理论中，许多实验变量（电场，表面电势，孔半径，介电常数，温度和盐浓度）通过单个通用参数出现。他们对聚合物孔隙附近的吸附区域的大小和易位率进行了定量预测。 （c）2007年美国物理研究所。

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