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首页> 外文期刊>The Journal of Chemical Physics >Forced dissociation of a biomolecular complex under periodic and correlated random forcing
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Forced dissociation of a biomolecular complex under periodic and correlated random forcing

机译：生物分子复合物在周期性和相关随机强迫作用下的强迫解离

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摘要

The dissociation of a biomolecular complex under the action of periodic and correlated random forcing is studied theoretically. The former is characterized by the period tau(p) and the latter by the correlation time tau(r). The rupture rates are calculated by overdamped Langevin dynamics and three distinct regimes are identified for both cases by comparison to local relaxation time tau(R) and bond lifetime 7). For periodic forcing, the adiabatic approximation cannot be applied in the regime tau(p) tau(R) and the bond lifetime is determined by the average pulling. As tau(R) tau(p) < T >, the rupture rate is enhanced by periodic forcing but is tau(p) independent. Analytical expressions are obtained for small and large force amplitudes. As < T > tau(p), the rupture rate depends on the phase lag and the process behaves like it is under constant force or loading rate. The result of correlated random forcing is similar to that of periodic forcing. Since the fluctuating forces greater than the average force < F > contribute more than the fluctuating forces less than < F >, the force fluctuations enhance the rupture rate. As < T > < tau(r), the pulling felt by the bond before rupture cannot follow the random forcing protocol and, thus, force fluctuations decline with increasing tau(r). (c) 2008 American Institute of Physics.
机译：理论上研究了在周期性和相关的随机强迫作用下生物分子复合物的解离。前者的特征在于周期tau（p），而后者的特征在于相关时间tau（r）。断裂率是由过度阻尼的兰根万能动力学计算得出的，并且通过与局部弛豫时间tau（R）和键的寿命进行比较，确定了两种情况下的三种不同状态。对于周期性强迫，绝热逼近不能在状态tau（p） tau（R）中应用，并且键合寿命由平均拉力确定。当tau（R） tau（p） 时，破裂率通过周期性强迫而增强，但与tau（p）无关。对于小和大的力振幅，获得解析表达式。当 tau（p）时，破裂率取决于相位滞后，过程的行为就像在恒定力或加载率下一样。相关随机强迫的结果类似于周期性强迫的结果。由于大于平均力的波动力的贡献大于小于的波动力的贡献，因此力的波动提高了破裂率。当

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