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首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >Human Monocytes Infected with Yersinia pestis Express Cell Surface TLR9 and Differentiate into Dendritic Cells
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Human Monocytes Infected with Yersinia pestis Express Cell Surface TLR9 and Differentiate into Dendritic Cells

机译：感染鼠疫耶尔森氏菌的人单核细胞表达细胞表面TLR9并分化为树突状细胞

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摘要

TLR9 recognizes DNA sequences containing hypomethylated CpG motifs and is a component of the innate immune system highly conserved during eukaryotic evolution.Previous reports suggested that the expression of TLR9 is restricted to plasmacytoid dendritic cells and B lymphocytes.Our results indicate that low levels of TLR9 are present on the cell surface of freshly isolated human monocytes,and expression is greatly increased by infection with Yersinia pestis.Enhanced cell surface TLR9 coincided with elevated levels of cytoplasmic TLR9 and recruitment of MyD88.Infected monocytes differentiated into mature dendritic cells,expressed IFN-alpha,and stimulated proliferatfve and cytotoxic T cell responses specific to Y.pestis.Furthermore,uninfected B cells and monocytes both increased cell surface TLR9,CD86,and HLA-DR in response to treatment with CpG-containing oligonu-cleotides,whereas cell surface TLR9 was down-modulated on infected dendritic cells by the addition of agonist oligonucleotide.Our results suggest that increased expression of TLR9 on the surface of infected cells may serve a role as an activation signal to other cells of the immune system.
机译：TLR9识别含有低甲基化CpG基序的DNA序列，并且是真核进化过程中高度保守的先天免疫系统的组成部分。以前的报道表明TLR9的表达仅限于浆细胞样树突状细胞和B淋巴细胞，我们的结果表明TLR9的水平低存在于新鲜分离的人单核细胞的细胞表面上，并通过鼠疫耶尔森氏菌感染大大提高了表达。细胞表面TLR9增强与胞质TLR9水平升高和MyD88募集相伴。被感染的单核细胞分化为成熟的树突状细胞，表达IFN-α而且，刺激未受感染的B细胞和单核细胞均增加了细胞表面TLR9，CD86和HLA-DR的反应，这是通过用含CpG的寡核苷酸-核苷酸处理而引起的，而细胞表面TLR9通过添加激动剂寡核苷酸在被感染的树突细胞上被下调。我们的结果表明，受感染细胞表面TLR9的表达增加可能充当免疫系统其他细胞的激活信号。

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