...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
【24h】

The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.

机译：IL-20亚家族细胞因子对重组人表皮的影响表明在牛皮癣的皮肤先天防御和病原体适应性免疫中可能发挥作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

IL-19, IL-20, IL-22, IL-24, and IL-26 are members of the IL-10 family of cytokines that have been shown to be up-regulated in psoriatic skin. Contrary to IL-10, these cytokines signal using receptor complex R1 subunits that are preferentially expressed on cells of epithelial origin; thus, we henceforth refer to them as the IL-20 subfamily cytokines. In this study, we show that primary human keratinocytes (KCs) express receptors for these cytokines and that IL-19, IL-20, IL-22, and IL-24 induce acanthosis in reconstituted human epidermis (RHE) in a dose-dependent manner. These cytokines also induce expression of the psoriasis-associated protein S100A7 and keratin 16 in RHE and cause persistent activation of Stat3 with nuclear localization. IL-22 had the most pronounced effects on KC proliferation and on the differentiation of KCs in RHE, inducing a decrease in the granular cell layer (hypogranulosis). Furthermore, gene expression analysis performed on cultured RHE treated with these cytokines showed that IL-19, IL-20, IL-22, and IL-24 regulate many of these same genes to variable degrees, inducing a gene expression profile consistent with inflammatory responses, wound healing re-epithelialization, and altered differentiation. Many of these genes have also been found to be up-regulated in psoriatic skin, including several chemokines, beta-defensins, S100 family proteins, and kallikreins. These results confirm that IL-20 subfamily cytokines are important regulators of epidermal KC biology with potentially pivotal roles in the immunopathology of psoriasis.
机译：IL-19，IL-20，IL-22，IL-24和IL-26是已被证明在牛皮癣皮肤中上调的细胞因子IL-10家族的成员。与IL-10相反，这些细胞因子利用受体复合物R1亚基发出信号，这些亚基优先在上皮起源的细胞上表达。因此，我们将它们称为IL-20亚家族细胞因子。在这项研究中，我们表明原代人角质形成细胞（KCs）表达这些细胞因子的受体，并且IL-19，IL-20，IL-22和IL-24以剂量依赖性诱导重组人表皮（RHE）中的棘皮症。方式。这些细胞因子还诱导银屑病相关蛋白S100A7和角蛋白16在RHE中的表达，并通过核定位引起Stat3的持续激活。 IL-22对RHE中的KC增殖和KC分化具有最明显的影响，导致颗粒细胞层减少（低粒细胞增多）。此外，对用这些细胞因子处理过的培养的RHE进行的基因表达分析表明，IL-19，IL-20，IL-22和IL-24可调节许多这些相同基因的程度，从而诱导了与炎症反应一致的基因表达谱，伤口愈合会重新上皮化，并改变分化。还发现许多这些基因在牛皮癣皮肤中被上调，包括几种趋化因子，β-防御素，S100家族蛋白和激肽释放酶。这些结果证实，IL-20亚家族细胞因子是表皮KC生物学的重要调节剂，在牛皮癣的免疫病理学中具有潜在的关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号