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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Sensitivity to interaural time differences in the inferior colliculus with bilateral cochlear implants.
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Sensitivity to interaural time differences in the inferior colliculus with bilateral cochlear implants.

机译：对双侧人工耳蜗下丘的耳间时间差异的敏感性。

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摘要

Bilateral cochlear implantation attempts to increase performance over a monaural prosthesis by harnessing the binaural processing of the auditory system. Although many bilaterally implanted human subjects discriminate interaural time differences (ITDs), a major cue for sound localization and signal detection in noise, their performance is typically poorer than that of normal-hearing listeners. We developed an animal model of bilateral cochlear implantation to study neural ITD sensitivity for trains of electric current pulses delivered via bilaterally implanted intracochlear electrodes. We found that a majority of single units in the inferior colliculus of acutely deafened, anesthetized cats are sensitive to ITD and that electric ITD tuning is as sharp as found for acoustic stimulation with broadband noise in normal-hearing animals. However, the sharpness and shape of ITD tuning often depended strongly on stimulus intensity; some neurons had dynamic ranges of ITD sensitivity as low as 1 dB. We also found that neural ITD sensitivity was best at pulse rates below 100 Hz and decreased with increasing pulse rate. This rate limitation parallels behavioral ITD discrimination in bilaterally implanted individuals. The sharp neural ITD sensitivity found with electric stimulation at the appropriate intensity is encouraging for the prospect of restoring the functional benefits of binaural hearing in bilaterally implanted human subjects and suggests that neural plasticity resulting from previous deafness and deprivation of binaural experience may play a role in the poor ITD discrimination with current bilateral implants.
机译：双侧人工耳蜗试图通过利用听觉系统的双耳处理来提高单耳假体的性能。尽管许多双边植入的人类对象区分了耳间时间差（ITD），这是声音中声音定位和信号检测的主要提示，但其性能通常比正常听众的性能差。我们开发了双侧耳蜗植入的动物模型，以研究神经ITD对通过双侧植入耳蜗内电极传递的电流脉冲序列的敏感性。我们发现，严重耳聋，麻醉的猫的下丘脑中的大多数单个单元对ITD敏感，而ITD电动调谐与正常听力动物的宽带噪声声刺激一样尖锐。但是，ITD调整的清晰度和形状通常很大程度上取决于刺激强度。一些神经元的ITD灵敏度动态范围低至1 dB。我们还发现，神经ITD灵敏度在100 Hz以下的脉冲频率下最佳，并随着脉冲频率的增加而降低。此速率限制与在双边植入的个体中的行为ITD歧视相似。在适当强度的电刺激下发现的尖锐的神经ITD敏感性，对于恢复双侧植入的人类受试者双耳听力的功能益处的前景令人鼓舞，并且表明先前耳聋和双耳经验剥夺导致的神经可塑性可能在当前双边植入物对ITD的歧视性较差。

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