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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Evidence for specialized rhythm-generating mechanisms in the adult mammalian spinal cord.
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Evidence for specialized rhythm-generating mechanisms in the adult mammalian spinal cord.

机译：成年哺乳动物脊髓中特殊的节律产生机制的证据。

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摘要

Locomotion and scratch are characterized by alternation of flexion and extension phases within one hindlimb, which are mediated by rhythm-generating circuitry within the spinal cord. By definition, the rhythm generator controls cycle period, phase durations, and phase transitions. The aim was to determine whether rhythm-generating mechanisms for locomotion and scratch are similar in adult decerebrate cats. The regulation of cycle period during fictive scratching was evaluated, as were the effects of specific sensory inputs on phase durations and transitions during spontaneous fictive locomotion and pinna-evoked fictive scratching. Results show that cycle period during fictive scratching varied predominantly with flexion phase duration, contrary to spontaneous fictive locomotion, where cycle period varied with extension phase duration. Ankle dorsiflexion greatly increased extension phase duration and cycle period during fictive locomotion but did not alter cycle period during scratching. Moreover, stimulating the plantaris (ankle extensor muscle) nerve during flexion reset the locomotor rhythm to extension but not the scratch rhythm. Stimulating the plantaris nerve during extension prolonged the extension phase and cycle period during fictive locomotion but not during fictive scratching. Stimulating the sartorius nerve (hip flexor muscle) during early flexion reduced the flexion phase and cycle period during fictive locomotion, but considerably prolonged the flexion phase and cycle period during fictive scratching. These data indicate that cycle period, phase durations, and phase transitions are not regulated similarly during fictive locomotion and scratching, with or without sensory inputs, providing evidence for specialized rhythm-generating mechanisms within the adult mammalian spinal cord.
机译：运动和刮擦的特征在于后肢弯曲和伸展阶段的交替，这是由脊髓内的节律产生电路介导的。根据定义，节奏发生器控制周期，相位持续时间和相位过渡。目的是确定成年无脑猫的运动和抓痒的节律产生机制是否相似。评估了虚构scratch抓过程中周期周期的调节，以及特定感觉输入对自发虚构运动和品脱诱发虚构scratch抓过程中相持续时间和过渡的影响。结果表明，虚构挠曲的周期主要随着屈曲阶段的持续时间而变化，这与自发虚构运动相反，自发虚构运动的周期随延伸阶段的持续时间而变化。脚踝背屈大大增加了虚构运动过程中的伸展期持续时间和周期，但并未改变抓挠过程中的周期。此外，在屈曲过程中刺激足底（踝伸肌）神经可使运动节律恢复到伸展状态，但不会使划伤节律恢复。在伸展过程中刺激plant神经延长了虚构运动期间的伸展阶段和周期，但在虚构scratch抓过程中并未延长。在早期屈曲过程中刺激缝线神经（髋屈肌）减少了虚构运动过程中的屈曲阶段和周期，但大大延长了虚构scratch抓过程中的屈曲阶段和周期。这些数据表明，在有或没有感觉输入的情况下，在虚构的运动和抓挠过程中，周期，相持续时间和相变的调控均不相同，这为成年哺乳动物脊髓内特殊的节律产生机制提供了证据。

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