...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Membrane Perturbation by the Lipopeptide Surfactin and Detergents as Studied by Deuterium NMR
【24h】

Membrane Perturbation by the Lipopeptide Surfactin and Detergents as Studied by Deuterium NMR

机译：通过氘核磁共振研究脂肽表面肌动蛋白和洗涤剂对膜的扰动

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Surfactin is a lipopeptide produced by bacillus subtilis,which has been shown to permeabilize cell and model membranes by an unspecific mechanism often referred to as detergent-like.We have compared the structural effects of surfactin on lipid membranes with those of two nonionic detergents,C_12EOe and C_12EO_8,by means of solid-state NMR of selectively deuterated lipids.The detergents exhibit the expected behavior of increasing the lateral pressure in the headgroup region and disordering the acyl chains.In contrast,the strong activity of surfactin to destabilize membranes is not reflected in an extreme disordering of the fatty acyl chains.However,surfactin tilts the acyl chains of the lipid and leads to a reorientation of the lipid headgroup toward the membrane interior.These effects provide evidence for a rather deep insertion of the peptide moiety into the hydrophobic-hydrophilic interface of the membrane.The results are discussed in terms of the molecular parameters governing the activity of a molecule to destabilize lipid membranes and the activity of antibiotic peptides to induce unspecific leakage of membranes.
机译：Surfactin是枯草芽孢杆菌产生的一种脂肽，已被证明可以通过一种非特异性机制（通常称为去污剂样）透化细胞和模型膜。我们将surfactin对脂质膜的结构作用与两种非离子去污剂C_12EOe的作用进行了比较和C_12EO_8，通过选择性氘化脂质的固态NMR分析。去污剂表现出预期的行为，即增加头基区域的侧向压力并扰乱酰基链。相反，表面活性剂对膜稳定的强大作用并未得到体现。然而，表面活性素会使脂质的酰基链倾斜并导致脂质头基朝向膜的内部重新定向。这些作用提供了将肽部分相当深地插入疏水基团的证据。膜的亲水性界面。根据控制分子结构的分子参数讨论了结果分子破坏脂膜的稳定性和抗生素肽诱导膜非特异性渗漏的活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号