To the editor:

Anindya Gupta

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To the editor:

机译：致编辑：

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Camilleri's assertion, made on the basis of experiments in animals, that an excess of short-chain fatty acids contributes to diarrhea-predominant IBS lacks construct validity in humans. Nonabsorbed carbohydrates are not absorbed in the colon and induce an osmotically mediated diarrhea. In contrast, short-chain fatty acids are absorbed by colonic epithelial cells by means of simple diffusion and ion exchange and are oxidized in the preferred order of butyrate, propionate, and then acetate, supplying 70% of the energy requirement of colonocytes in the process. Short-chain fatty acids stimulate sodium-dependent fluid absorption by means of a cyclic AMP-independent process. Diarrhea results from the inhibition of synthesis of short-chain fatty acids by antibiotics. In contrast, the increased production of short-chain fatty acids as a result of providing starch that is relatively resistant to amylase digestion in oral rehydration solution represents an important approach for improving the effectiveness of treatment of acute diarrhea in children under the age of 5 years.

机译：Camilleri的断言是根据动物实验得出的结论，即短链脂肪酸过多会导致腹泻为主的IBS在人体中缺乏构造效度。未吸收的碳水化合物在结肠中不吸收，并引起渗透性腹泻。相反，短链脂肪酸通过简单的扩散和离子交换方式被结肠上皮细胞吸收，并以丁酸，丙酸和乙酸盐的优选顺序被氧化，在此过程中提供了结肠细胞能量需求的70％。短链脂肪酸通过不依赖环AMP的过程刺激钠依赖性流体吸收。腹泻是由于抗生素对短链脂肪酸合成的抑制。相反，由于在口服补液溶液中提供相对抗淀粉酶消化的淀粉，短链脂肪酸的产量增加代表了一种提高5岁以下儿童急性腹泻治疗效果的重要方法。。

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《The New England journal of medicine》 |2013年第6期|共1页
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Anindya Gupta;
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