Tuberculosis vaccine trials

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Tuberculosis vaccine trials

机译：结核疫苗试验

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Michele Tameris and colleagues' data (March 23, p 1021)1 offer a valuable opportunity to reflect on the utility of diagnostic approaches for tuberculosis in the clinical trial setting.In this study, a hierarchical approach was used for diagnosis of tuberculosis consisting of progressively less stringent endpoints 1, 2, and 3.1 Although unstated, there was also an implicit endpoint 0, microbiologically confirmed tuberculosis, which was a subset of endpoint 1 (microbiological confirmation or a combination of other predefined criteria predictive of tuberculosis).

机译：Michele Tameris及其同事的数据（3月23日，第1021页）1提供了宝贵的机会来反思结核病诊断方法在临床试验环境中的实用性。在这项研究中，分层方法被用于逐步诊断包括较不严格的端点1、2和3.1，尽管未声明，但也有一个隐含的端点0，即微生物学确认的结核病，它是端点1的子集（微生物学确认或其他预测结核病的预定标准的组合）。

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《The Lancet》 |2013年第9885期|共2页
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1. Safety and Immunogenicity of Adenovirus 35 Tuberculosis Vaccine Candidate in Adults with Active or Previous Tuberculosis A Randomized Trial [J] . Richard N. van Zyl-Smit, Aliasgar Esmail, Mary E. Bateman, American journal of respiratory and critical care medicine . 2017,第9期

机译：患有活动性或先前结核病的成人中腺病毒35结核疫苗候选者的安全性和免疫原性随机试验
2. Improved CD4(+) T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: A randomized trial [J] . Leroux-Roels Isabel, Forgus Sheron, De Boever Fien, Vaccine . 2013,第17期

机译：与M72 / AS02和Mtb72F / AS02结核候选疫苗制剂相比，M72 / AS01改善了PPD阴性成人对结核分枝杆菌的CD4（+）T细胞应答：一项随机试验
3. A Phase Ha Trial of the New Tuberculosis Vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-Infected Adults [J] . Thomas J. Scriba, Michele Tameris, Erica Smit, American journal of respiratory and critical care medicine . 2012,第7期

机译：HIV和/或结核分枝杆菌感染的成年人中的新结核病疫苗MVA85A的Ha期试验
4. Evaluation of the efficacy of RUTI and ID93/GLA-SE vaccines in tuberculosis treatment: in silico trial through UISS-TB simulator [C] . Giulia Russo, Francesco Pappalardo, Miguel A. Juarez, IEEE International Conference on Bioinformatics and Biomedicine . 2019

机译：评估RUTI和ID93 / GLA-SE疫苗在结核病治疗中的功效：通过UISS-TB模拟器进行的计算机模拟试验
5. Early Immunity to Mycobacterium tuberculosis: New Insights into Macrophage Heterogeneity and Vaccine-mediated Responses [D] . Delahaye, Jared L. 2019

机译：提前抗癌性结核病：新洞察巨噬细胞异质性和疫苗介导的反应
6. Lessons from the first clinical trial of a non-licensed vaccine among Ugandan adolescents: a phase II field trial of the tuberculosis candidate vaccine MVA85A [O] . Anne Wajja, Milly Namutebi, Barbara Apule, -1

机译：乌干达青少年中无牌疫苗的首次临床试验的经验教训：结核病候选疫苗MVA85A的II期现场试验
7. Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial. [O] . Rowland, R, Pathan, AA, Satti, I, 2013

机译：在BCG疫苗接种的健康成人中，单独和与候选疫苗MVA85A一起使用FP9载体的候选结核病疫苗（FP85A）的安全性和免疫原性：I期临床试验。

Tuberculosis vaccine trials

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