Platelet reactivity after coronary stenting

PriceM.J.

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Platelet reactivity after coronary stenting

机译：冠状动脉支架置入术后的血小板反应性

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Major adverse cardiovascular events after percutaneous coronary intervention (PCI) are driven in large part by platelet activation and aggregation. Clopidogrel, a platelet P2Y12 adenosine diphosphate (ADP)-receptor inhibitor, reduces such events when combined with aspirin after acute coronary syndrome and PCI, albeit with more bleeding. However, the antiplatelet effect of clopidogrel varies quite substantially between individuals. Although the goal of antiplatelet therapy is obviously to inhibit platelet activity, the clinical implications of response variability have led to much debate, particularly within the context of recent, negative trials of platelet function testing to guide antiplatelet therapy after PCI. In The Lancet, Gregg Stone and colleagues6 report the results of the ADAPT-DES registry, the largest observational study to date on testing of platelet function after PCI. Although many questions remain, this seminal study moves the debate from whether testing of platelet function is biologically relevant to how and when it should be used clinically.

机译：经皮冠状动脉介入治疗（PCI）后的主要不良心血管事件在很大程度上是由血小板活化和聚集引起的。氯吡格雷，一种血小板P2Y12二磷酸腺苷（ADP）受体抑制剂，在急性冠脉综合征和PCI后与阿司匹林合用时，尽管出血更多，但能减少此类事件。但是，氯吡格雷的抗血小板作用在个体之间差异很大。尽管抗血小板治疗的目标显然是抑制血小板活性，但是反应变异性的临床意义引起了很多争论，特别是在最近进行的血小板功能测试阴性试验指导PCI后抗血小板治疗的背景下。在《柳叶刀》杂志上，Gregg Stone及其同事6报告了ADAPT-DES注册表的结果，该注册表是迄今为止PCI后血小板功能测试中规模最大的观察性研究。尽管仍然存在许多问题，但这项开创性的研究将辩论从血小板功能测试是否在生物学上与应如何在临床上使用以及何时应使用生物学相关。

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《The Lancet》 |2013年第9892期|共2页
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PriceM.J.;
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1. A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: Results of the TRIGGER-PCI (Testing Platelet Reactivity in Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy with Prasugrel) study [J] . TrenkD., StoneG.W., GawazM., Journal of the American College of Cardiology . 2012,第24期

机译：普拉格雷与氯吡格雷在经皮冠状动脉介入治疗并植入药物洗脱支架后对氯吡格雷具有高血小板反应性的患者的随机试验：TRIGGER-PCI（在接受氯吡格雷选择性支架置入术的患者中测试血小板反应性以指导替代疗法）与普拉格雷（Prasugrel）研究
2. Prognostic value of a high on-clopidogrel treatment platelet reactivity in bivalirudin versus abciximab treated non-ST-segment elevation myocardial infarction patients: ISAR-REACT 4 (Intracoronary stenting and antithrombotic regimen: Rapid early action for coronary treatment-4) platelet substudy [J] . SibbingD., BernlochnerI., SchulzS., Journal of the American College of Cardiology . 2012,第5期

机译：比伐卢定与阿昔单抗治疗的非ST段抬高型心肌梗死患者中氯吡格雷治疗后血小板反应性高的预后价值：ISAR-REACT 4（冠状动脉内支架和抗血栓治疗方案：冠状动脉治疗的快速早期行动-4）血小板亚研究
3. Baseline platelet size is increased in patients with acute coronary syndromes developing early stent thrombosis and predicts future residual platelet reactivity. A case-control study. [J] . Huczek Z, Filipiak KJ, Kochman J, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2010,第5期

机译：患有早期冠状动脉血栓形成的急性冠状动脉综合征患者的基线血小板大小会增加，并预测未来残余的血小板反应性。病例对照研究。
4. The Long-Term Clinical Results of a Platelet Glycoprotein Ilb/IIIa Receptor Blocker (Abciximab: ReoPro~R)-Coated Stent in Patients with Coronary Artery Disease [C] . W. Kim, M.H. Jeong, Y.J. Hong, International Congress on Thrombosis . 2004

机译：冠状动脉疾病患者的血小板糖蛋白ILB / IIIA受体阻滞剂（Abciximab：Reopro〜R）涂层支架的长期临床结果
5. Predictors of early saphenous vein graft patency, platelet hyper-reactivity and aspirin-insensitive thromboxane generation in patients undergoing coronary artery bypass graft surgery. [D] . Nazarian, Susanna M. 2009

机译：冠状动脉搭桥手术患者早期大隐静脉移植物通畅性，血小板高反应性和阿司匹林不敏感血栓烷生成的预测指标。
6. Association between High Platelet Reactivity Following Dual Antiplatelet Therapy and Ischemic Events in Japanese Patients with Coronary Artery Disease Undergoing Stent Implantation [O] . Masakatsu Nishikawa, Yoshihiro Takeda, Naoei Isomura, 2020

机译：日本冠状动脉支架植入术患者的双重抗血小板治疗后高血小板反应性与缺血事件之间的关系
7. A Randomized Trial of Prasugrel Versus Clopidogrel in Patients With High Platelet Reactivity on Clopidogrel After Elective Percutaneous Coronary Intervention With Implantation of Drug-Eluting Stents Results of the TRIGGER-PCI (Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugrel) Study [O] . Universitaets-Herzzentrum Freiburg-Bad Krozingen, Klinik fuer Kardiologie und Angiologie, Bad Krozingen, Germany ( host institution ), Trenk, Dietmar ( author ), Stone, Gregg W. ( author ), 2012

机译：选择性药物经皮冠状动脉介入治疗并植入药物洗脱支架后，氯吡格雷对血小板反应性高的普拉格雷与氯吡格雷的随机对照试验采用TRIGGER-PCI结果（测试在氯吡格雷上进行选择性支架置入术的患者的血小板反应性，以指导其他治疗普拉格雷（Prasugrel）研究

Platelet reactivity after coronary stenting

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