Cryoglobulinaemia identified by repeated analytical failure of laboratory tests

Hira-KazalR.; SayarZ.; KothariJ.; AyrtonP.; BerneyS.; MaherJ.

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Cryoglobulinaemia identified by repeated analytical failure of laboratory tests

机译：通过实验室测试的反复分析失败确定低温球蛋白血症

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A 68-year-old man came to his general practitioner in July, 2013, with headache and intermittent haematuria. Previous cystoscopy was normal. Biochemical profile and full blood count were requested but samples were unsuitable for analysis. Repeat testing was attempted on three occasions over the ensuing 8 days, but all were rejected similarly.To investigate, serum was retrieved from the laboratory and noted to have an unusual viscous character (figure), prompting consideration of a hyperviscosity state. The patient was referred to haematology where he appeared remarkably well, having played 4 sets of tennis 3 days earlier. Direct questioning elicited a history of mild generalised pruritus, Raynaud's phenomenon, episodic dizziness, and blurred vision. No other B-symptoms (symptoms associated with lymphoma: fevers, night sweats, and weight loss), organomegaly, or lymphaden-opathy were present. Blood film showed red cell agglutination and platelet clumping.

机译：2013年7月，一名68岁的男子因头痛和间歇性血尿来到他的全科医生。先前的膀胱镜检查是正常的。要求生化分析和全血细胞计数，但样品不适合分析。在随后的8天中，尝试了3次重复测试，但均被拒绝。为进行研究，从实验室取回血清，发现血清具有异常的粘性特征（图），提示考虑了高粘度状态。该患者被转诊至血液学，他表现得非常出色，三天前打了四组网球。直接询问会引起轻度全身瘙痒，雷诺现象，发作性头晕和视物模糊的病史。没有其他B症状（与淋巴瘤相关的症状：发烧，盗汗和体重减轻），器官肿大或淋巴结肿大。血膜显示红细胞凝集和血小板结块。

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《The Lancet》 |2014年第9914期|共1页
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Hira-KazalR.; SayarZ.; KothariJ.; AyrtonP.; BerneyS.; MaherJ.;
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Cryoglobulinaemia identified by repeated analytical failure of laboratory tests

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