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Influenza vaccination and risk of hospitalization among adults with laboratory confirmed influenza illness

机译：患有实验室确诊的流感疾病的成年人中的流感疫苗接种和住院风险

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Background: Influenza vaccine is moderately effective for preventing influenza illness. It is not known if vaccination reduces the risk of subsequent hospital admission among patients with vaccine failure and laboratory confirmed influenza illness. Methods: Patients in a community cohort presenting with acute respiratory illness were prospectively enrolled and tested for influenza during 8 seasons to estimate seasonal vaccine effectiveness. Hospital admissions within 14 days after illness onset were identified for all participants aged >= 20 years with laboratory confirmed influenza. The association between vaccination and hospital admission was examined in a propensity score adjusted logistic regression model. The model was validated by examining the association between vaccination and hospital admission in participants without influenza. Results: Influenza was identified in 1393(28%) of 4996 participants. Sixty-two (6%) of 1020 with influenza A and 17 (5%) of 369 with influenza B were hospitalized. Vaccination was not associated with a reduced risk of hospital admission among all participants with influenza [adjusted odds ratio (aOR) = 1.08; 95% CI: 0.62, 1.88]; or among those with influenza A (aOR = 1.35; 95% CI: 0.71, 2.57) or influenza B (aOR = 0.67; 95% CI: 0.21, 2.15). Influenza vaccination was not associated with hospitalization after non-influenza respiratory illness (aOR = 1.14; 95% CI: 0.84, 1.54). Conclusions: Influenza vaccination did not reduce the risk of subsequent hospital admission among patients with vaccine failure. These findings do not support the hypothesis that vaccination mitigates influenza illness severity
机译：背景：流感疫苗在预防流感疾病方面具有中等效力。目前尚不清楚疫苗接种是否会降低疫苗失败和实验室确诊的流感疾病患者随后入院的风险。方法：前瞻性招募社区队列中出现急性呼吸道疾病的患者，并在8个季节内进行流感检测，以评估季节性疫苗的有效性。对于所有≥20岁且实验室确诊为流感的参与者，确定其发病后14天内的医院入院率。在倾向评分调整的逻辑回归模型中检查了疫苗接种和入院之间的关联。通过检查无流感参与者的疫苗接种与入院之间的关联来验证该模型。结果：在4996名参与者中，有1393名（28％）发现了流感。 1020例A型流感患者中有62名（6％）和369例B型流感患者中有17名（5％）。在所有流感患者中，接种疫苗与降低入院风险没有关系[校正比值比（aOR）= 1.08; 95％CI：0.62，1.88];或患有甲型流感（aOR = 1.35; 95％CI：0.71、2.57）或乙型流感（aOR = 0.67; 95％CI：0.21、2.15）的患者。非流感性呼吸道疾病后，流感疫苗接种与住院无关（aOR = 1.14; 95％CI：0.84、1.54）。结论：流感疫苗接种并未降低疫苗失败患者随后入院的风险。这些发现不支持疫苗接种可减轻流感疾病严重性的假设

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