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NIAID meeting report: Improving malaria vaccine strategies through the application of immunological principles

机译：NIAID会议报告：通过应用免疫原理改善疟疾疫苗策略

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A highly efficacious vaccine to prevent malaria infection or clinical disease is still far from reality despite several decades of intensive effort and a growing global commitment in malaria vaccine development. Further understanding of the mechanisms required for induction of effective host immune responses and maintenance of long-term protective immunity is needed to facilitate rational approaches for vaccine design and evaluation. The National Institute of Allergy and Infectious Diseases (NIAID) conducted a workshop on June 18-19, 2012 with experts in the fields of malaria vaccine development, malaria immunology, and basic immunology to address issues associated with improving our current understanding of malaria vaccine immunity. This report summarizes the discussion and major recommendations generated by the workshop participants regarding the application of recent advances in basic immunology and state-of-the-art immunological tools to improve progress and help address current challenges and knowledge gaps in malaria vaccine development.
机译：尽管数十年来付出了巨大的努力，并且全球对疟疾疫苗的开发投入越来越高，但预防疟疾感染或临床疾病的高效疫苗仍远未实现。需要进一步了解诱导有效宿主免疫应答和维持长期保护性免疫所需要的机制，以促进疫苗设计和评估的合理方法。美国国家过敏和传染病研究所（NIAID）于2012年6月18日至19日与疟疾疫苗开发，疟疾免疫学和基础免疫学领域的专家举行了研讨会，以解决与改善我们对疟疾疫苗免疫力的现有理解有关的问题。 。本报告总结了研讨会参与者关于应用基础免疫学的最新进展和最新的免疫学工具以改善进展并帮助应对疟疾疫苗开发方面的当前挑战和知识差距的讨论和主要建议。

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