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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Structural and redox requirements for the action of anti-diabetic vanadium compounds
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Structural and redox requirements for the action of anti-diabetic vanadium compounds

机译：抗糖尿病钒化合物作用的结构和氧化还原要求

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摘要

This study presents the first systematic investigation of the antidiabetic properties of non-oxido V~(IV) complexes. In particular, the insulin-mimetic activity of [V~(IV)(taci)_2]~(4+), [V~(IV)(inoH_(?3))_2]~(2?), [V~(IV)(dhab)_2], [V~(IV)(hyph~(Ph))_2], [V~(IV)(cat)_3]~(2?) and [V~(IV)(pdbh)_2] – where taci is 1,3,5-triamino-1,3,5-trideoxy-cis-inositol, ino is cis-inositol, H_2dhab is 2,2'-dihydroxyazobenzene, H_2hyph~(Ph) is 3,5-bis(2-hydroxyphenyl)- 1H-1,2,4-triazole, H_2cat is catechol and H_2pdbh is pentan- 2,4-dione benzoylhydrazone – was evaluated in terms of free fatty acid (FFA) release. Among the six compounds examined, only [V~(IV)(pdbh)_2], [V~(IV)(cat)_3]~(2?) and [V~(IV)(hyph~(Ph))_2], which at the physiological pH convert to the corresponding V~(IV)O complexes, were found to exhibit a significant insulin-mimetic activity compared to VOSO_4. In contrast, [V(taci)_2]~(4+), [V(inoH_(?3))_2]~(2?) and [V(dhab)_2], which at pH 7.4 keep their 'bare' non-oxido structure, did not cause any inhibition of FFA. The results, therefore, suggest that a V~(IV)O functionality is necessary for vanadium complexes to exhibit anti-diabetic effects. This agrees with the notion that the biotransformations of V compounds in the organism are more important than the nature of the species.
机译：这项研究是对非氧化性V〜（IV）配合物的抗糖尿病特性的首次系统研究。尤其是[V〜（IV）（taci）_2]〜（4 +），[V〜（IV）（inoH _（？3））_ 2]〜（2？），[V〜 （IV）（dhab）_2]，[V〜（IV）（hyph〜（Ph））_ 2]，[V〜（IV）（cat）_3]〜（2？）和[V〜（IV）（pdbh ）_2] –其中taci是1,3,5-三氨基-1,3,5-三苯氧基-顺式肌醇，ino是顺式肌醇，H_2dhab是2,2'-二羟基偶氮苯，H_2hyph〜（Ph）是3， 5-双（2-羟苯基）-1H-1,2,4-三唑，H_2cat是儿茶酚，H_2pdbh是戊丹-2,4-二酮苯甲酰hydr-根据游离脂肪酸（FFA）释放进行了评估。在所研究的六种化合物中，只有[V〜（IV）（pdbh）_2]，[V〜（IV）（cat）_3]〜（2？）和[V〜（IV）（hyph〜（Ph））_ 2发现在生理pH下可转化为相应的V〜（IV）O复合物的1，1]与VOSO_4相比具有显着的模拟胰岛素的活性。相反，[V（taci）_2]〜（4 +），[V（inoH _（？3））_ 2]〜（2？）和[V（dhab）_2]在pH 7.4时保持其“裸露”状态非氧化结构，对FFA没有任何抑制作用。因此，结果表明，钒配合物必须具有V〜（IV）O官能团才能发挥抗糖尿病作用。这与生物中V化合物的生物转化比物种的性质更为重要的观点相吻合。

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