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首页> 外文期刊>Current Biology: CB >Novel functions for integrins in epithelial morphogenesis
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Novel functions for integrins in epithelial morphogenesis

机译：整合素在上皮形态发生中的新功能

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摘要

Dorsal closure during Drosophila embryogenesis provides a valuable model for epithelial morphogenesis and wound healing. Previous studies have focused on two cell populations, the dorsal epidermis and the extraembryonic amnioserosa [1, 2]. Here, we demonstrate that there is an additional player, the large yolk cell. We find that integrins are expressed in the amnioserosa and yolk cell membrane and that they are required for three processes: (1) assembly of an intervening extracellular matrix, (2) attachment between these two cell layers, and (3) contraction of the amnioserosa cells. We also provide evidence for integrin-extracellular matrix interactions occurring between the lateral surfaces of the amnioserosa cell and the leading edge epidermis that effectively mediate cell-cell adhesion. Thus, dorsal closure shares mechanistic similarities with vertebrate epithelial morphogenetic events, including epiboly [3], that also employ an underlying substrate.
机译：果蝇胚胎发生过程中的背侧闭合为上皮形态发生和伤口愈合提供了有价值的模型。先前的研究集中在两个细胞群，即背侧表皮和胚外羊膜[1，2]。在这里，我们证明了还有一个额外的参与者，即大蛋黄细胞。我们发现整联蛋白在羊膜和卵黄细胞膜中表达，它们是三个过程所必需的：（1）介入细胞外基质的组装，（2）这两个细胞层之间的附着以及（3）羊膜的收缩细胞。我们还提供了在羊膜细胞的侧面与有效调节细胞间粘附的前缘表皮之间发生整合素-细胞外基质相互作用的证据。因此，背侧闭合与脊椎动物上皮形态发生事件（包括表皮[3]）具有相似的机制，后者也采用了潜在的底物。

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