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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >DMSO containing ruthenium(II) hydrazone complexes: in vitro evaluation of biomolecular interaction and anticancer activity
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DMSO containing ruthenium(II) hydrazone complexes: in vitro evaluation of biomolecular interaction and anticancer activity

机译：含钌（II）complex配合物的DMSO：生物分子相互作用和抗癌活性的体外评估

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摘要

Synthesis, spectral, electrochemical and single crystal X-ray diffraction data of a new series of DMSO containing bivalent ruthenium hydrazone complexes are presented. XRD data of two of the new complexes revealed an octahedral coordination around the ruthenium ion satisfied by NOS_2Cl_2 atoms. Electrochemical studies showed the metal centred, quasi-reversible, one-electron redox behaviour of the new complexes. The binding of these complexes with biomolecules such as calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) protein investigated by different spectrophotometric methods revealed an intercalative mode of interaction. The in vitro cytotoxicity of these complexes evaluated by the MTT assay on a panel of cancer and normal cell lines indicated that the above complexes are more toxic to cancer cells with a few micromolar concentrations as the IC_(50) value, but are significantly less toxic to normal cell lines. The observed variations in the binding interactions and cytotoxicity of the complexes were attributed to the nature of the hydrazide moiety of the hydrazones that influences their biological activities.
机译：提出了一系列新的含二价钌配合物的DMSO系列的合成，光谱，电化学和单晶X射线衍射数据。两个新配合物的XRD数据显示，NOS_2Cl_2原子满足了钌离子周围的八面体配位。电化学研究表明，新配合物的金属居中，准可逆，单电子氧化还原行为。通过不同的分光光度法研究这些复合物与小分子胸腺DNA（CT-DNA）和牛血清白蛋白（BSA）等生物分子的结合，揭示了相互作用的嵌入模式。通过MTT分析在一组癌细胞和正常细胞系上评估的这些复合物的体外细胞毒性表明，上述复合物对癌细胞的毒性更高，IC_（50）值为几微摩尔浓度，但毒性明显较低正常细胞系。观察到的复合物的结合相互作用和细胞毒性的变化归因于nes的酰肼部分的性质，这影响了它们的生物学活性。

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