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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Enzyme and voltage stimuli-responsive controlled release system based on beta-cyclodextrin-capped mesoporous silica nanoparticles
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Enzyme and voltage stimuli-responsive controlled release system based on beta-cyclodextrin-capped mesoporous silica nanoparticles

机译：基于β-环糊精封端的介孔二氧化硅纳米粒子的酶和电压刺激响应控制释放系统

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摘要

Enzyme and voltage stimuli are more biologically compatible in the field of stimuli-responsive systems and release systems based on beta-cyclodextrin (CD) and ferrocene (Fc) have attracted much attention. Herein, mesoporous silica nanoparticles (MSNs) have been functionalized with the ferrocenyl moiety (Fc) which interacts with beta-cyclodextrin (beta-CD) to form an inclusion complex on the opening of the pores. The size of the inclusion complex results in a barrier to the opening of the pores. Based on these characteristics, MSNs with nanovalves have been developed as a release system. The release system shows a clear response to heme protein (horseradish peroxidase or hemoglobin) and H2O2, glucose oxidase (GOD) with horseradish peroxidase (HRP) and glucose, or +1.5 V based on an oxidation stimulus mechanism. Modulating the amount of enzyme or the discretion of the voltage makes the release system a controlled one.
机译：酶和电压刺激在刺激响应系统领域具有更高的生物相容性，基于β-环糊精（CD）和二茂铁（Fc）的释放系统引起了广泛关注。在此，介孔二氧化硅纳米颗粒（MSN）已被二茂铁基部分（Fc）官能化，该二茂铁基部分与β-环糊精（β-CD）相互作用，在孔的开口处形成了包合物。包合物的尺寸导致对孔的开放的阻挡。基于这些特性，已开发出具有纳米阀的MSN作为释放系统。释放系统显示出对血红素蛋白（辣根过氧化物酶或血红蛋白）和H2O2，葡萄糖氧化酶（GOD）和辣根过氧化物酶（HRP）和葡萄糖的清晰响应，或者基于氧化刺激机制的+1.5V。调节酶的量或电压的自由度使释放系统成为受控系统。

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