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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Metal complex interactions with DNA
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Metal complex interactions with DNA

机译：金属络合物与DNA的相互作用

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Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic and genomic methods. The diversity of transition metal complexes is also growing, as the unique contributions that transition metals bring to the overall structure of metal complexes depend on the various coordination numbers, geometries, physiologically relevant redox potentials, as well as kinetic and thermodynamic characteristics. The vast range of ligands that can be utilised must also be considered. Given this diversity, a variety of biological interactions is not unexpected. Specifically, interactions with negatively-charged DNA can arise due to covalent/coordinate or subtle non-coordinate interactions such as electrostatic attraction, groove binding and intercalation as well as combinations of all of these modes. The potential of metal complexes as therapeutic agents is but one aspect of their utility. Complexes, both new and old, are currently being utilised in conjunction with spectroscopic and biological techniques to probe the interactions of DNA and its many structural forms. Here we present a review of metal complex-DNA interactions in which several binding modes and DNA structural forms are explored.
机译：使用生物物理，光谱学和基因组方法揭示了越来越多的DNA结构。过渡金属配合物的多样性也在不断增长，因为过渡金属对金属配合物整体结构的独特贡献取决于各种配位数，几何形状，生理相关的氧化还原电势以及动力学和热力学特征。还必须考虑可以利用的大量配体。鉴于这种多样性，各种生物相互作用并不意外。具体地，由于共价/配位或微妙的非配位相互作用，例如静电引力，凹槽结合和嵌入以及所有这些模式的组合，可能产生与带负电荷的DNA的相互作用。金属络合物作为治疗剂的潜力只是其实用性的一方面。目前，无论是新的还是旧的复合物，都已与光谱和生物技术结合使用，以探测DNA及其许多结构形式的相互作用。在这里，我们介绍金属络合物-DNA相互作用的综述，其中探讨了几种结合模式和DNA结构形式。

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