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首页> 外文期刊>Journal of Applied Polymer Science >Properties of chitosan/poly(vinyl alcohol) films for drug-controlled release
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Properties of chitosan/poly(vinyl alcohol) films for drug-controlled release

机译：壳聚糖/聚乙烯醇薄膜控释特性

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With bovine serum albumin (BSA) as a model drug, drug-loaded films of chitosan (CS) and poly(vinyl alcohol) (PVA) were obtained by a casting/solvent evaporation method and crosslinked by tripolyphosphate (TPP). The films were characterized by FTIR, XRD, and SEM. The influential factors of drug-loaded films on drug-controlled release were studied. These factors included, primarily, the component ratio of CS and PVA, the loaded amount of BSA, the pH and ionic strength of the release solution, and the crosslinking time with TPP. The results showed that within 25 h, when the weight ratios of CS to PVA in the drug-loaded films were 90: 10, 70: 30, 50: 50, and 30: 50, the cumulative release rates of BSA were 63.3, 72.9, 81.8, and 91.8%, respectively; when the amounts of model drug were 0.1, 0.2, and 0.3 g, the release rates were 100, 81.8, and 59.6%, respectively; when the pH values of the drug release medium were 1.0, 3.8, 5.4, and 7.4, the release rates reached 100, 100, 37.9, and 7.8%, respectively; the cumulative release rates of BSA were 78.4, 82.3, 84.3, and 91.7% when the ionic strengths of the release solution were, respectively, 0.1, 0.2, 0.3, and 0.4M; when the crosslinking times of these drug films in the TPP solution were 0, 5, 105, 30, and 60 min, the release rates attained 100, 100, 81.8, 65, and 43.3%, respectively. All the results indicated that the CS/PVA film was useful in drug delivery systems. (c) 2005 Wiley Periodicals, Inc.
机译：以牛血清白蛋白（BSA）为模型药物，通过流延/溶剂蒸发法获得壳聚糖（CS）和聚乙烯醇（PVA）的载药膜，并通过三聚磷酸酯（TPP）交联。膜通过FTIR，XRD和SEM表征。研究了载药薄膜对控释的影响。这些因素主要包括CS和PVA的组分比率，BSA的负载量，脱模溶液的pH和离子强度以及与TPP的交联时间。结果表明，在25 h内，载药薄膜中CS与PVA的重量比为90：10、70：30、50：50和30:50时，BSA的累积释放率为63.3、72.9 ，分别为81.8和91.8％;当模型药物的量为0.1、0.2和0.3 g时，释放率分别为100、81.8和59.6％;当药物释放介质的pH值为1.0、3.8、5.4和7.4时，释放率分别达到100、100、37.9和7.8％。当释放溶液的离子强度分别为0.1、0.2、0.3和0.4M时，BSA的累积释放率为78.4、82.3、84.3和91.7％;当这些药物膜在TPP溶液中的交联时间为0、5、105、30和60分钟时，释放率分别达到100％，100％，81.8％，65％和43.3％。所有结果表明，CS / PVA膜可用于药物输送系统。 （c）2005年Wiley Periodicals，Inc.

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