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首页> 外文期刊>Journal of Applied Polymer Science >Levitation and movement of tripalmitin-based cationic lipospheres on a dielectrophoresis-based lab-on-a-chip device
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Levitation and movement of tripalmitin-based cationic lipospheres on a dielectrophoresis-based lab-on-a-chip device

机译：在基于介电泳的芯片实验室设备上，基于tripalmitin的阳离子脂质球的悬浮和运动

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Dielectrophoresis (DEP) is a very valuable approach for designing and developing laboratory-on-a-chip (lab-on-a-chip) devices that are able to manipulate microparticles and cells. Lab-on-a-chip technology will enable laboratory testing to move from laboratories using complex equipment to nonlaboratory settings. We used a lab-on-a-chip device, the SmartSlide, which carries 193 parallel electrodes and generates up to 50 cylinder-shaped DEP cages able to entrap microparticles and cells within DEP cages and move them along the chip. For lab-on-a-chip technology, the characterization of microparticles exhibiting a differential ability to be DEP-caged, levitated, and moved is important for the development of both diagnostic and therapeutic protocols. We determined whether the SmartSlide could be used to levitate and move tripalmitin-based lipospheres carrying increasing concentrations of dihexadecyl dimethyl ammonium bromide (DHDAB) as a cationic surfactant. The data obtained with this DEP-based platform showed that DEP caging, levitation, and movement of the cationic lipospheres depended on the percentage of DHDAB. Tripalmitin lipospheres containing 6% DHDAB could be DEP-caged and manipulated. On the contrary, lipospheres containing 12% DHDAB did not exhibit an efficient ability to be DEP-caged and moved throughout the chip. To our knowledge, this is the first report on the possible use of a DEP-based lab-on-a-chip device for guided manipulation of lipospheres. This information might be of interest in the fields of drug discovery, delivery, and diagnosis. (c) 2008 Wiley Periodicals, Inc.
机译：介电电泳（DEP）是一种非常有价值的方法，用于设计和开发能够操纵微粒和细胞的芯片实验室（lab-on-a-chip）设备。芯片实验室技术将使实验室测试从使用复杂设备的实验室转变为非实验室环境。我们使用了芯片实验室设备SmartSlide，该设备带有193个平行电极，最多可生成50个圆柱DEP笼，能够将微粒和细胞捕获在DEP笼中并沿芯片移动。对于芯片实验室技术而言，表征具有不同能力进行DEP封闭，悬浮和移动的微粒的表征对于诊断和治疗方案的开发都很重要。我们确定了SmartSlide是否可用于悬浮和移动基于三棕榈精的脂球，并携带浓度不断增加的阳离子阳离子表面活性剂二十六烷基二甲基溴化铵（DHDAB）。使用基于DEP的平台获得的数据表明，阳离子脂球的DEP笼蔽，悬浮和运动取决于DHDAB的百分比。含有6％DHDAB的Tripalmitin脂球可以进行DEP笼罩和操作。相反，含有12％DHDAB的脂球没有表现出DEP笼罩和在整个芯片中移动的有效能力。就我们所知，这是有关基于DEP的芯片实验室设备可能用于脂球的指导操作的第一份报告。该信息可能在药物发现，递送和诊断领域中令人感兴趣。 （c）2008 Wiley期刊公司

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