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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis and evaluation of a star amphiphilic block copolymer from poly(ε-caprolactone) and poly(ethylene oxide) as load and release carriers for guest molecules
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Synthesis and evaluation of a star amphiphilic block copolymer from poly(ε-caprolactone) and poly(ethylene oxide) as load and release carriers for guest molecules

机译：聚（ε-己内酯）和聚（环氧乙烷）作为客体分子的负载和释放载体的星形两亲嵌段共聚物的合成和评价

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摘要

The use of polymeric materials as the carrier in the controlled release of guest molecules has become an important research area in the polymeric materials science, because of their advantages of the safety, efficacy and patient convenience. One of them, star amphiphilic polymer can self-assemble into supermolecular structure (polymer micelles) by the balance of hydrophilic and hydrophobic interaction. In this study, star amphiphilic copolymer consisting of hydrophobic and biodegradable poly(ε-aprolactone) (PCL) and hydrophilic poly(ethylene oxide) (PEO) blocks were synthesized by two-step ring-opening polymerization. The resultant polymer was characterizated by FTIR, ~1H-NMR, and DSC to determine its chemical structure. The morpholoy of the polymer micelles was analyzed by TEM. Using star-PCL-b-PEO as carriers and congo red as model guest molecules, the encapsulation and release properties were investigated by UV-visable analysis.
机译：由于其安全性，功效和患者便利性的优点，在客体分子的受控释放中使用聚合物材料作为载体已成为聚合物材料科学中的重要研究领域。其中之一，星形两亲聚合物可以通过亲水和疏水相互作用的平衡而自组装成超分子结构（聚合物胶束）。在这项研究中，通过两步开环聚合反应合成了由疏水性和可生物降解的聚（ε-丙内酯）（PCL）和亲水性聚环氧乙烷（PEO）嵌段组成的星形两亲共聚物。通过FTIR，〜1H-NMR和DSC对所得聚合物进行表征，以确定其化学结构。通过TEM分析聚合物胶束的形态。以star-PCL-b-PEO为载体，刚果红为模型客体分子，通过紫外可见分析研究了其包封和释放性能。

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