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首页> 外文期刊>Journal of Applied Polymer Science >Electrospun PEG-PLA nanofibrous membrane for sustained Release of hydrophilic antibiotics
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Electrospun PEG-PLA nanofibrous membrane for sustained Release of hydrophilic antibiotics

机译：电纺丝PEG-PLA纳米纤维膜，用于持续释放亲水性抗生素

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摘要

Reported in this study is the successful incorporation of a hydrophilic antibiotic drug, tetracycline hydrochloride (TCH), into electrospun PEG-PLA nanofibrous membrane without loss of its bioactivity. Degradation behavior of the copolymer was studied in vitro. Release behavior of TCH from the electrospun membrane and antimicrobial effects of the TCH-loaded membrane against Staphylococcus aureus culture were investigated. The medicated nanofibrous membrane demonstrated sustained release of TCH over 6 days and was found to be effective in inhibiting growth of S. aureus. In addition, increasing the antibiotic drug content in the electrospun membranes was found to enhance the anti-bacterial effectiveness of the medicated fiber mats. And the combination of mechanical barriers provided by the electrospun biodegradable nanofibrous membranes and their capability of local sustained delivery of antibiotics made these membranes more useful in biomedical applications, particularly as new wound dressings for ulcers caused by diabetes or other diseases, and to provide a better means of treatment for these malignant wounds and ulcers.
机译：该研究报道的是成功地将亲水性抗生素药物盐酸四环素（TCH）掺入到静电纺丝PEG-PLA纳米纤维膜中，而不会丧失其生物活性。在体外研究了共聚物的降解行为。研究了TCH从电纺膜上的释放行为以及TCH膜对金黄色葡萄球菌培养物的抗菌作用。含药的纳米纤维膜在6天内显示出TCH的持续释放，被发现可有效抑制金黄色葡萄球菌的生长。另外，发现增加电纺膜中的抗生素药物含量可以增强含药纤维垫的抗菌效果。电纺生物可降解纳米纤维膜提供的机械屏障及其局部持续递送抗生素的能力的结合，使这些膜在生物医学应用中更加有用，特别是作为由糖尿病或其他疾病引起的溃疡的新型伤口敷料，并提供了更好的这些恶性伤口和溃疡的治疗手段。

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