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首页> 外文期刊>Journal of Applied Polymer Science >Microanohybrid hierarchical poly(N-isopropylacrylamide)/calcium carbonate composites for smart drug delivery
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Microanohybrid hierarchical poly(N-isopropylacrylamide)/calcium carbonate composites for smart drug delivery

机译：微/纳米杂化聚（N-异丙基丙烯酰胺）/碳酸钙复合材料，用于智能药物输送

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摘要

Poly(N-isopropylacrylamide) (PNIPAAm)/calcium carbonate (CaCO_3) microanohybrid composites with smart drug-delivery property had been prepared via in situ biomineralization reaction. Sodium poly(styrene sulfonate) (PSS) was used as the crystal growth additive to control the crystalline polymorph of CaCO_3 and the morphology of the hybrid materials. The interaction between PSS and Ca~(2+) contributed to the formation of hierarchical microanohybrid composites, in which microscale vaterite microparticles were covered by nanoscale PNIPAAm micelle. Vitamin B_2 (VB_2) release behavior was found to be pH~- and thermal-responsive. Moreover, the release profiles were sustained with the introduction of CaCO_3 microparticles, suggesting that CaCO_3 microparticles could hinder the permeation of the encapsulated VB_2 and reduce the drug release effectively. The prepared microanohybrid materials can be used as "smart" hierarchical materials for controlled drug delivery.
机译：通过原位生物矿化反应制备了具有智能药物传递性能的聚（N-异丙基丙烯酰胺）/碳酸钙（CaCO_3）微/纳米杂化复合材料。聚（苯乙烯磺酸钠）（PSS）用作晶体生长添加剂，以控制CaCO_3的晶体多晶型物和杂化材料的形貌。 PSS和Ca〜（2+）之间的相互作用促进了分层微/纳米杂化复合物的形成，其中微米级球rite石微粒被纳米级PNIPAAm胶束覆盖。发现维生素B_2（VB_2）的释放行为具有pH响应和热响应。此外，通过引入CaCO_3微粒可以维持释放曲线，这表明CaCO_3微粒可能会阻碍包封的VB_2的渗透并有效降低药物的释放。制备的微/纳米杂化材料可以用作“智能”分级材料以控制药物的输送。

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