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首页> 外文期刊>Journal of Applied Polymer Science >Gelatin-Carbohydrate Phase-Separated Hydrogels as Bioactive Carriers in Vaginal Delivery: Preparation and Physical Characterizations
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Gelatin-Carbohydrate Phase-Separated Hydrogels as Bioactive Carriers in Vaginal Delivery: Preparation and Physical Characterizations

机译：明胶-碳水化合物相分离的水凝胶在阴道分娩中作为生物活性载体：制备和物理表征

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The current study focuses on the alteration of properties of the gelatin hydrogels using polysaccharides (e.g., maltodextrin, dextran, and sodium carboxymethyl cellulose) for probable use in vaginal delivery of antimicrobials. The hydrogels were prepared by varying the proportions of gelatin and polysaccharides and were characterized by microscopy, mechanical testing, and impedance spectroscopy. Metronidazole (MZ), drug of choice for the treatment of bacterial vaginosis, was incorporated within the hydrogels. In vitro release studies of MZ from the hydrogels was studied in-depth using modified Franz's diffusion cell. Antimicrobial efficiency of the MZ-loaded hydrogels was tested against E. coli and B. subtilis. The results suggested that the incorporation of polysaccharides resulted in the phase-separated hydrogels. The properties of the hydrogels was found be suitable for vaginal delivery. The drug release and antimicrobial efficiency from the hydrogels suggested that the developed hydrogels may be used for the delivery of antimicrobials in the vaginal lumen.
机译：当前的研究集中在使用多糖（例如麦芽糖糊精，右旋糖酐和羧甲基纤维素钠）改变明胶水凝胶的性质，以用于阴道抗菌剂的递送。通过改变明胶和多糖的比例制备水凝胶，并通过显微镜，机械测试和阻抗谱对其进行表征。甲硝唑（MZ）是治疗细菌性阴道病的首选药物，已掺入水凝胶中。使用改良的Franz扩散池深入研究了MZ从水凝胶中的体外释放研究。测试了负载MZ的水凝胶对大肠杆菌和枯草芽孢杆菌的抗菌效率。结果表明，多糖的掺入导致相分离的水凝胶。发现水凝胶的性质适合于阴道递送。水凝胶的药物释放和抗菌效率表明，开发的水凝胶可用于阴道腔内抗菌剂的递送。

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