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首页> 外文期刊>Journal of Applied Polymer Science >Enzymatic and Ionic Crosslinked Gelatin/K-Carrageenan IPN Hydrogels as Potential Biomaterials
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Enzymatic and Ionic Crosslinked Gelatin/K-Carrageenan IPN Hydrogels as Potential Biomaterials

机译：酶和离子交联明胶/ K-卡拉胶IPN水凝胶作为潜在的生物材料

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摘要

Hydrogels of a natural origin have attracted considerable attention in the field of tissue engineering due to their resemblance to ECM, defined degradability and compatibility with biological systems. In this study, we introduced carrageenan into a gelatin network, creating IPN hydrogels through biological methods of enzymatic and ionic crosslinking. Their gelation processes were monitored and confirmed by rheology analysis. The combination of biochemical and physical crosslinking processes enables the formation of biohydrogels with tunable mechanical properties, swelling ratios and degradation behaviors while maintaining the biocompatibilities of natural materials. The mechanical strength increased with an increase in carrageenan content while swelling ratio and degradability decreased correspondingly. In addition, the IPN hydrogels were shown to support adhesion and proliferation of L929 cell line. All the results highlighted the use of biological crosslinked gelatin-carrageenan IPN hydrogels in the context of tissue engineering. VC 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 10.1002/app.40975.
机译：天然来源的水凝胶因其与ECM相似，确定的可降解性以及与生物系统的相容性而在组织工程领域引起了相当大的关注。在这项研究中，我们将角叉菜胶引入了明胶网络中，通过酶和离子交联的生物学方法创建了IPN水凝胶。监测其胶凝过程并通过流变学分析确认。生化和物理交联过程的结合使得能够形成具有可调节的机械性能，溶胀比和降解行为的生物水凝胶，同时保持天然材料的生物相容性。机械强度随角叉菜胶含量的增加而增加，而溶胀率和可降解性则相应降低。此外，显示IPN水凝胶可支持L929细胞系的粘附和增殖。所有结果都突出了在组织工程领域中生物交联的明胶-角叉菜胶IPN水凝胶的使用。 VC 2014 Wiley Periodicals，Inc. J. Appl。 Polym。科学2014，131，10.1002 / app.40975。

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