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首页> 外文期刊>Journal of Applied Polymer Science >Poly(ε-caprolactone)-Graft-Poly(N-isopropylacrylamide) Amphiphilic Copolymers Prepared by a Combination of Ring-Opening Polymerization and Atom Transfer Radical Polymerization: Synthesis, Self-Assembly, and Thermoresponsive Property
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Poly(ε-caprolactone)-Graft-Poly(N-isopropylacrylamide) Amphiphilic Copolymers Prepared by a Combination of Ring-Opening Polymerization and Atom Transfer Radical Polymerization: Synthesis, Self-Assembly, and Thermoresponsive Property

机译：开环聚合与原子转移自由基聚合相结合制备的聚（ε-己内酯）-接枝-聚（N-异丙基丙烯酰胺）两亲共聚物：合成，自组装和热响应性

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摘要

Thermoresponsive graft copolymers of ε-caprolactone and N-isopropylacrylamide were synthesized by a combination of ring-opening polymerization and the sequential atom transfer radical polymerization (ATRP). The copolymer composition, chemical structure, and the self-assembled structure were characterized. The graft length and density of the copolymers were well controlled by varying the feed ratio of monomer to initiator and the fraction of chlorides along PCL backbone, which is acting as the macroinitiator for ATRP. In aqueous solution, PCL-g-PNIPAAm can assemble into the spherical micelles which comprise of the biodegradable hydrophobic PCL core and thermoresponsive hydrophilic PNIPAAm corona. The critical micelle concentrations of PCL-g-PNIPAAm were determined under the range of 6.4–23.4 mg/L, which increases with the PNIPAAm content increasing. The mean hydrodynamic diameters of PCL-g-PNIPAAm micelles depend strongly on the graft length and density of the PNIPAAm segment, allowing to tune the particle size within a wide range. Additionally, the PCL-g-PNIPAAm micelles exhibit thermosensitive properties and aggregate when the temperature is above the lower critical solution temperature.
机译：ε-己内酯和N-异丙基丙烯酰胺的热敏接枝共聚物是通过开环聚合和顺序原子转移自由基聚合（ATRP）的方法合成的。表征了共聚物的组成，化学结构和自组装结构。共聚物的接枝长度和密度可以通过改变单体与引发剂的进料比和氯化物沿PCL主链的比例来控制，而PCL主链是ATRP的大分子引发剂。在水溶液中，PCL-g-PNIPAAm可以组装成球形胶束，该球形胶束包含可生物降解的疏水PCL核和热响应性亲水PNIPAAm电晕。 PCL-g-PNIPAAm的临界胶束浓度在6.4-23.4 mg / L范围内确定，随PNIPAAm含量的增加而增加。 PCL-g-PNIPAAm胶束的平均流体动力学直径很大程度上取决于PNIPAAm片段的接枝长度和密度，从而可以在较宽的范围内调节粒径。另外，当温度高于下临界溶液温度时，PCL-g-PNIPAAm胶束表现出热敏特性并聚集。

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