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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis, Self-Assembly, and Drug Release Behavior of Star-Shaped Poly(ε-caprolactone)-b-Poly(ethylene oxide) Block Copolymer with Porphyrin Core
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Synthesis, Self-Assembly, and Drug Release Behavior of Star-Shaped Poly(ε-caprolactone)-b-Poly(ethylene oxide) Block Copolymer with Porphyrin Core

机译：卟啉核星型聚（ε-己内酯）-b-聚（环氧乙烷）嵌段共聚物的合成，自组装和释药行为

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摘要

A serial of star-shaped poly(ε-caprolactone)-b-poly(ethylene oxide) (SPPCL-b-PEO) block copolymers with porphyrin core were successfully synthesized from ring-opening polymerization (ROP) of ε-caprolactone (CL) initiated with porphyrin core, followed by coupling reaction with a hydrophilic polymer poly(ethylene oxide) (PEO) shell. The structure of this novel copolymer were synthesized and thoroughly characterized by Nuclear Magnetic Resonance (NMR), Gel Permeation Chromatography (GPC), Fourier Transform Infrared Spectroscopy (FTIR). Notably, the as-prepared porphyrin-cored star-shaped copolymer could self-assembly into different structures determined by transmission electron microscopy (TEM) and dynamic lighting scattering (DLS), which provides the great potential of using this well-defined photodynamic therapy material for drug delivery system. Particularly, the doxorubicinloaded SPPCL-b-PEO nanosphere exhibits property of pH-induced drug release. VC 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40996.
机译：从ε-己内酯（CL）的开环聚合（ROP）成功合成了一系列具有卟啉核的星形聚（ε-己内酯）-b-聚环氧乙烷（SPPCL-b-PEO）嵌段共聚物。用卟啉核引发，然后与亲水聚合物聚环氧乙烷（PEO）壳偶联反应。合成了这种新型共聚物的结构，并通过核磁共振（NMR），凝胶渗透色谱（GPC），傅立叶变换红外光谱（FTIR）进行了全面表征。值得注意的是，制备的卟啉核星型共聚物可以通过透射电子显微镜（TEM）和动态光散射（DLS）自组装成不同的结构，这为使用这种定义明确的光动力疗法材料提供了巨大潜力用于药物输送系统。特别地，负载阿霉素的SPPCL-b-PEO纳米球表现出pH诱导的药物释放特性。 VC 2014 Wiley Periodicals，Inc. J. Appl。 Polym。科学2014，131，40996。

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