Anti-IgE therapy in allergic asthma.

Rolinck Werninghaus C; Wahn U; Hamelmann E

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Anti-IgE therapy in allergic asthma.

机译：抗过敏性哮喘的抗IgE治疗。

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摘要

Despite the advanced and increasing understanding of the pathophysiology of asthma and other allergic diseases, current treatment remains unspecific and targets late events within the allergic cascade. Therefore, a novel and promising approach to treat allergic asthma is antagonizing IgE by anti-IgE antibodies. This review analyzes the role of IgE for the pathology of asthma, summarize the current data about action, safety and efficacy of anti-IgE therapy, and tries to give a rational approach for future indications and directions of treatment with anti-IgE antibodies.

机译：尽管对哮喘和其他变态反应性疾病的病理生理学有了越来越高的了解，但当前的治疗方法仍不明确，并且针对变应性级联反应中的晚期事件。因此，治疗变应性哮喘的新颖且有希望的方法是通过抗IgE抗体拮抗IgE。这篇综述分析了IgE在哮喘病理中的作用，总结了有关抗IgE治疗的作用，安全性和有效性的最新数据，并试图为抗IgE抗体的未来适应症和治疗方向提供合理的方法。

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《Current Drug Targets-Inflammation & Allergy》 |2005年第5期|共14页
作者
Rolinck Werninghaus C; Wahn U; Hamelmann E;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Asthma; Immunoglobulin E measurement; Therapeutic procedure; anti-IgE; therapeutic aspects; 哮喘;

机译：哮喘;免疫球蛋白E的测定;治疗程序;抗IgE;治疗方面;疾病;

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专利

1. Anti-IgE therapy with omalizumab decreases endothelin-1 in exhaled breath condensate of patients with severe persistent allergic asthma. [J] . Zietkowski Z, Skiepko R, Tomasiak Lozowska MM, Respiration: International Review of Thoracic Diseases . 2010,第6期

机译：omalizumab的抗IgE治疗可降低严重持续性过敏性哮喘患者呼出气冷凝物中的内皮素-1。
2. Anti-IgE and other new immunomodulation-based therapies for allergic asthma. [J] . Jonkers RE, van der Zee JS The Netherlands journal of medicine. . 2005,第4期

机译：抗IgE和其他新的基于免疫调节的过敏性哮喘疗法。
3. Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma. [J] . Corren J, Casale T, Deniz Y, The Journal of Allergy and Clinical Immunology . 2003,第1期

机译：重组人源化抗IgE抗体Omalizumab可减少过敏性哮喘患者与哮喘相关的急诊室就诊和住院次数。
4. Anti-IgE Treatment Overcomes Intolerability of Honeybee- Venom Ultra-Rush Immunotherapy in Indolent Systemic Mastocytosis [C] . B. Wedi, D. Wieczorek, U. Raap, Collegium Internationale Allergologicum . 2007

机译：抗IgE治疗克服了蜜腺超鼠疫免疫疗法在惰性全身乳细胞诱变中的不耐受性
5. Delineating signaling mechanisms involved in lymphocyte chemotaxis, immune homeostasis and allergic asthma. [D] . Wanjara, Steve Biko. 2015

机译：描述淋巴细胞趋化，免疫稳态和过敏性哮喘的信号传导机制。
6. Sublingual immunotherapy with a carbamylated monomeric allergoidin cat-allergic patients suffering from rhinoconjunctivitis and/or allergic asthma. A multicenter cross-sectional survey [O] . Bettina Hauswald 2015

机译：对患有鼻结膜炎和/或变应性哮喘的羧化单体变应敏蛋白猫变态反应患者进行舌下免疫治疗。多中心横截面调查
7. A PHASE I, SINGLE-BLIND STUDY TO DETERMINE THE SAFETY, TOLERANCE, PHARMACOKINETICS AND PHARMACODYNAMICS OF ANTI-IgE RECOMBINANT HUMANIZED MONOCLONAL ANTIBODY E25 (rhu MAb-E25) IN ADOLESCENTS AND CHILDREN WITH MODERATE TO SEVERE ALLERGIC ASTHMA. 39 [O] . D Bisberg, J Froehlich, M Schoenhoff, 1996

机译：I阶段，单盲研究，以确定抗IgE重组人源化单克隆抗体E25（RHU mAb-E25）在青少年和中度至严重过敏性哮喘中的儿童中的安全性，耐受性，药代动力学和药效学和药效学。 39.

Anti-IgE therapy in allergic asthma.

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