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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Retention and selectivity of stationary phases for hydrophilic interaction chromatography
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Retention and selectivity of stationary phases for hydrophilic interaction chromatography

机译：亲水相互作用色谱的固定相保留和选择性

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摘要

More and more polar stationary phases have become available for the separation of small polar compounds in the past decade as hydrophilic interaction chromatography (HILIC) continues to find applications in new fields (e.g., metabolomics and proteomics). Bare silica phases remain popular, especially in the bio-analytical area. A wide range of functional groups (e.g., amino, amide, diol, sulfobetaine, and triazole) have been employed as polar stationary phases for HILIC separation. This review provides a survey of the popular stationary phases commercially available and discusses the retention and selectivity characteristics of the polar stationary phases in HILIC. The purpose of the review is not to provide a comprehensive overview of literature reports, but rather focuses on findings that demonstrate retention and selectivity of the polar stationary phases in HILIC.
机译：在过去的十年中，随着亲水相互作用色谱（HILIC）继续在新领域（例如，代谢组学和蛋白质组学）中找到应用，越来越多的极性固定相可用于分离小极性化合物。裸露的二氧化硅相仍然很受欢迎，尤其是在生物分析领域。多种官能团（例如氨基，酰胺，二醇，磺基甜菜碱和三唑）已被用作用于HILIC分离的极性固定相。这篇综述提供了对商业上流行的固定相的调查，并讨论了HILIC中极性固定相的保留和选择性特征。审查的目的不是提供文献报道的全面概述，而是着眼于证明HILIC中极性固定相的保留和选择性的发现。

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