The RNA Response to DNA Damage

Giono Luciana E.; Nieto Moreno Nicolas; Cambindo Botto Adrian E.; Dujardin Gwendal; Munoz Manuel J.; Kornblihtt Alberto R.

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The RNA Response to DNA Damage

机译：RNA对DNA损伤的反应

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Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis. This entails regulation of a variety of cellular processes: DNA replication and transcription, RNA processing, mRNA translation and turnover, and post-translational modification, degradation, and relocalization of proteins.

机译：多细胞生物必须确保基因组完整性，以防止突变积累，细胞死亡和癌症。 DNA损伤反应（DDR）是一个复杂的网络，可以感应，发出信号并执行多个程序，包括DNA修复，细胞周期停滞，衰老和凋亡。这需要调节多种细胞过程：DNA复制和转录，RNA加工，mRNA翻译和周转，以及蛋白质的翻译后修饰，降解和重新定位。

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来源
《Journal of Molecular Biology》 |2016年第12期|共16页
作者
Giono Luciana E.; Nieto Moreno Nicolas; Cambindo Botto Adrian E.; Dujardin Gwendal; Munoz Manuel J.; Kornblihtt Alberto R.;
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正文语种 eng
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关键词
DNA damage response; p53; RNA processing; alternative splicing; ncRNAs;

机译：DNA损伤反应;p53;RNA加工;选择性剪接;ncRNA;

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1. RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci [J] . Michelini Flavia, Rossiello Francesca, di Fagagna Fabrizio dAdda, Nature protocols erecipes for researchers . 2019,第5期

机译：RNase一种用DNA损伤反应RNA在活细胞中的治疗和重构作为研究非编码RNA在DNA损伤反应焦点形成中的作用的工具
2. DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs [J] . Francesca Rossiello, Julio Aguado, Sara Sepe, Nature Communications . 2017,第1期

机译：通过调节端粒DNA损伤反应RNA抑制功能失调的端粒的DNA损伤反应
3. DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors [J] . Francia Sofia, Cabrini Matteo, Matti Valentina, Journal of Cell Science . 2016,第7期

机译：DICER，DROSHA和DNA损伤反应RNA对于DNA损伤反应因子的二次募集是必需的
4. A Mathematical Modelling for Estradiol Influence on DNA Damage Response and G1/S Transition Phase Regulations in Early Stage of Breast Cancer [C] . Mayang Fati Kusuma, Fajar Adi-Kusumo International Conference on Mathmatics and Its Applications . 2019

机译：雌二醇对乳腺癌早期DNA损伤反应和G1 / S转变阶段规范的数学建模
5. A Synthetic Circuit for Control of the Bacterial DNA Damage Response Without DNA Damage [D] . Kubiak, Jeffrey M. 2018

机译：用于控制细菌DNA损伤反应的合成电路，没有DNA损伤
6. DICER DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors [O] . Sofia Francia, Matteo Cabrini, Valentina Matti, -1

机译：DICERDROSHA和DNA损伤反应RNA对于DNA损伤反应因子的二次募集是必需的
7. Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs [O] . Ubaldo Gioia, Sofia Francia, Matteo Cabrini, 2019

机译：DNA损伤反应和通过增强DNA损伤反应的生物发生响应和修复药理促进RNA
8. Transcriptomics, DNA Damage and DNA Damage Response in Space. [R] . Wu, H. 2017

机译：转录组学，DNa损伤和空间DNa损伤反应。

The RNA Response to DNA Damage

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