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首页> 外文期刊>Current opinion in obstetrics & gynecology >Borderline ovarian tumours: a review of the recent literature.
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Borderline ovarian tumours: a review of the recent literature.

机译：卵巢交界性肿瘤：近期文献综述。

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摘要

PURPOSE OF REVIEW: Borderline tumors of the ovary are seen commonly in obstetrics and gynecology practices. This review will outline the most recent information regarding the epidemiology, molecular pathogenesis, pathology, and clinical management of these tumors. RECENT FINDINGS: In the past, borderline ovarian tumors and invasive ovarian cancer were studied together, under the presumption that they represent a continuum of disease. This view is coming into question based on both epidemiological and molecular biological studies. Pathologists are increasingly able to identify poor prognostic histological features. This has not yet been translated into improved non-surgical therapy. Surgical management to excise all visible tumor remains the cornerstone of therapy. Because borderline ovarian tumors often occur in reproductive-age women, fertility is an important issue. Conservative surgery is safe in carefully selected patients. SUMMARY: Our growing understanding of the relatively benign natural historyof borderline ovarian tumors has allowed us to be more conservative in their surgical management, preserving fertility in many young women. A few women will be affected by a more virulent form of the disease with the potential to recur and cause death. The pathological features that identify patients with a poor prognosis are progressively being elucidated. Surgery remains the most effective therapy for these patients. Effective non-surgical therapies have yet to be identified. Hopefully, as molecular biological studies continue to expand our understanding of this disease as probably a separate carcinogenic process from invasive ovarian cancer, we will be able to employ this knowledge to design novel adjuvant therapies.
机译：审查目的：卵巢交界性肿瘤常见于产科和妇科实践。这篇综述将概述有关这些肿瘤的流行病学，分子发病机制，病理学和临床管理的最新信息。最近的发现：过去，人们在假设交界性卵巢肿瘤和浸润性卵巢癌代表疾病的连续性的同时，对其进行了研究。基于流行病学和分子生物学研究，这种观点正受到质疑。病理学家越来越能够识别不良的预后组织学特征。尚未将其转化为改善的非手术治疗。切除所有可见肿瘤的手术管理仍然是治疗的基石。由于卵巢交界性肿瘤通常发生在育龄妇女中，因此生育能力是一个重要问题。保守手术对于经过精心挑选的患者是安全的。摘要：我们对交界性卵巢肿瘤相对良性自然史的认识不断提高，这使我们在外科手术治疗方面更为保守，从而保持了许多年轻女性的生育能力。少数妇女将受到更强毒的疾病的影响，有可能复发并导致死亡。逐步阐明可识别预后不良的病理特征。对于这些患者，手术仍然是最有效的疗法。有效的非手术疗法尚未确定。希望随着分子生物学研究的不断深入，我们对这种疾病的理解可能是与浸润性卵巢癌分开的单独的致癌过程，我们将能够利用这一知识来设计新颖的辅助疗法。

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