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首页> 外文期刊>International Journal of Cardiology >Effect of nicorandil on clinical outcomes in patients with ST-segment elevation and non-ST-segment elevation myocardial infarction: Based on the Korea Acute Myocardial Infarction Registry (KAMIR)
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Effect of nicorandil on clinical outcomes in patients with ST-segment elevation and non-ST-segment elevation myocardial infarction: Based on the Korea Acute Myocardial Infarction Registry (KAMIR)

机译：Nicorandil对ST段抬高和非ST段抬高心肌梗死患者临床结果的影响：基于韩国急性心肌梗死登记处（kamir）

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摘要

Nicorandil has vasodilatory effect, anti-inflammatory effect, ischemic preconditioning effect, prevention of microvascular vasospasm, anti-arrhythmic effect and improvement of microcirculation through adenosine triphosphate (ATP)-sensitive K+ channel. So, nicorandil reduced adverse cardiac event patients with STEMI [1,2]. We have analyzed the Korea Acute Myocardial Infarction Registry (KAMIR) to estimate the effects of oral nicorandil administration on clinical outcome patients who have STEMI and non-ST segment elevation myocardial infarction (NSTEMI).A total of 6370 patients with STEMI and 4180 patients with NSTEMI had been diagnosed from the year 2005 to 2008. KAMIR is a national multicenter registry that is the data collected by multicenter, from the fifty number of hospital available primary PCI in Korea. This study is the retrospective analysis based on KAMIR data. All patients gave written informed consent to participate in the KAMIR registry. STEMI was defined as patients with chest discomfort that develop ST elevation in two contiguous leads and elevate cardiac biomarker. In contrast, patients without ST elevation at presentation are defined as having a NSTEMI.
机译：Nicorandil具有血管舒张效应，抗炎作用，缺血性预处理效果，预防微血管血管痉挛，通过腺苷三磷酸腺苷（ATP） - 密度K +通道进行抗心律失常效果和微循环的改善。所以，尼罗兰人减少了干扰的心脏事件患者[1,2]。我们已经分析了韩国急性心肌梗死登记处（Kamir）来估算口服Nicorandil管理对具有STEMI和非ST段抬高心肌梗死（NSTEMI）的临床结果患者的影响。总共6370名患者，4180名患者Nstemi已被诊断为2005年至2008年。Kamir是一个国家多中心注册处，是多中心收集的数据，来自韩国的五十多个医院可用的主要PCI。本研究是基于kamir数据的回顾性分析。所有患者均提供书面知情同意参加Kamir登记处。 Stemi被定义为胸部不适的患者，在两个连续的引线和升高的心脏生物标志物中产生ST升高。相比之下，没有ST展示的患者被定义为具有nstemi。

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  • 作者

    YangM.J.; LeeH.C.; LeeH.W.; ParkJ.S.; OhJ.-H.; ChoiJ.H.; ChaK.S.; KimS.-P.; KimW.; JeongM.H.;

  • 作者单位

    Division of Cardiology Department of Internal Medicine Busan Medical Center Busan South Korea;

    Department of Internal Medicine College of Medicine Pusan National University 10 Ami-dong 1-ga;

    Department of Internal Medicine College of Medicine Pusan National University 10 Ami-dong 1-ga;

    Department of Internal Medicine College of Medicine Pusan National University 10 Ami-dong 1-ga;

    Department of Internal Medicine College of Medicine Pusan National University 10 Ami-dong 1-ga;

    Department of Internal Medicine College of Medicine Pusan National University 10 Ami-dong 1-ga;

    Department of Internal Medicine College of Medicine Pusan National University 10 Ami-dong 1-ga;

    Department of Thoracic and Cardiovascular Surgery Pusan National University Hospital Busan South;

    Department of Internal Medicine Kyung Hee University Kyung Hee University Hospital Seoul South;

    Department of Internal Medicine Chonnam National University Chonnam National University Hospital;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 心脏、血管（循环系）疾病;
  • 关键词

    Angioplasty; Myocardial infarction; Nicorandil;

    机译：血管成形术;心肌梗死;尼罗兰;

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