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首页> 外文期刊>Life sciences >Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts
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Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts

机译：II型糖尿病促进心脏成纤维细胞中的肌纤维细胞表型

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摘要

Aims Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition remain unclear. The goal of this study was to evaluate whether cardiac fibroblast function is altered in a rat model of type II DM. Main methods Cardiac fibroblasts were isolated from 14 week old Zucker diabetic and lean control (LC) adult male rat hearts. Fibroblasts were examined for their ability to remodel 3-dimensional collagen matrices, their adhesion, migration and proliferation on collagen and changes in gene expression associated with collagen remodeling. Key findings Cardiac fibroblasts from diabetic animals demonstrated significantly greater ability to contract 3-dimensional collagen matrices compared to cardiac fibroblasts from LC animals. The enhanced contractile behavior was associated with an increase in diabetic fibroblast proliferation and elevated expression of ??-smooth muscle actin and type I collagen, suggesting the transformation of diabetic fibroblasts into a myofibroblast phenotype. Significance Cardiac fibrosis is a common complication in diabetic cardiomyopathy which may contribute to the observed cardiac dysfunction associated with this disease. Identifying and understanding the changes in fibroblast behavior which contribute to the increased deposition of collagen and other matrix proteins may provide novel therapeutic targets for reducing the devastating effects of diabetes on the heart. ? 2013 Elsevier Inc.
机译：目标心血管疾病是诊断型患有II型糖尿病（DM）的个体死亡原因。心脏功能的变化，患者和动物模型都描述了糖尿病的患者和糖尿病的血液功能;然而，介导增加的基质沉积的因素仍然不清楚。本研究的目标是评估心肌成纤维细胞是否在II型DM的大鼠模型中改变。主要方法心脏成纤维细胞从14周龄Zucker糖尿病和瘦对照（LC）成年男性大鼠心中分离。检查成纤维细胞的能力改造三维胶原基质的能力，它们对胶原蛋白的粘附，迁移和增殖以及与胶原重塑相关的基因表达的变化。与来自LC动物的心脏成纤维细胞相比，来自糖尿病动物的主要发现来自糖尿病动物的心脏成纤维细胞的能力显着更大。增强的收缩行为与糖尿病成纤维细胞增殖的增加相关，升高的肌肉肌动蛋白和I型胶原蛋白的表达升高有关，表明糖尿病成纤维细胞的转化为肌纤维细胞表型。显着性心肌纤维化是糖尿病心肌病的常见并发症，这可能导致观察到与这种疾病相关的心脏功能障碍。鉴定和理解有助于增加胶原蛋白和其他基质蛋白的沉积增加的成纤维细胞行为的变化可以提供新的治疗靶标，用于降低心脏对心脏糖尿病的破坏性作用。还是2013年elsevier公司

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  • 来源
    《Life sciences》 |2013年第11期|共8页
  • 作者

    FowlkesV.; ClarkJ.; FixC.; LawB.A.; MoralesM.O.; QiaoX.; Ako-AsareK.; GoldsmithJ.G.; CarverW.; MurrayD.B.; GoldsmithE.C.;

  • 作者单位

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

    Department of Pharmacology University of Mississippi School of Pharmacy Oxford MS 38677 United;

    Department of Cell Biology and Anatomy University of South Carolina School of Medicine 6439;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    Collagen; Diabetes; Extracellular matrix; Fibroblast; Heart;

    机译：胶原蛋白;糖尿病;细胞外基质;成纤维细胞;心脏;

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