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Cardiac dysfunction in diabetes

机译:糖尿病心脏功能障碍

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摘要

Diabetes is a complex, poorly understood disease that has reached epidemic levels worldwide, with impact on multiple organ systems. Based upon 2011 statistics, nearly 26 million people in the United States are diabetic, with an additional 70 million classified as pre-diabetic (CDC Diabetes Fact Sheet, 2011). This epidemic rise in diabetes rates has no indication of reducing; on the contrary, evidence indicates that diabetes is on the rise in the young, with roughly 1 in 400 adolescents newly diagnosed with diabetes. There is no denying the link between diabetes and cardiac dysfunction, as diabetic cardio-myopathy is a well-known consequence of sustained diabetes (Kamalesh, 2007; Witteles and Fowler, 2008; Miki et al., 2012; Murarka and Movahed, 2010). Nearly 70% of diabetes-related deaths are linked to heart disease, with diabetics suffering a two- to four-fold greater death rate due to heart disease than non-diabetics (CDC Diabetes Fact Sheet, 2011). Despite these sobering clinical statistics, there is still little understanding of how diabetes impacts cardiac function. However, studies indicate that diabetes adversely affects many aspects necessary for proper cardiac function, including cardiomyocyte metabolism, pro-survival signaling and calcium handling, and also induces vascular and cardiac fibrosis (Kamalesh, 2007; Kota et al., 2011; Law et al., 2012; Ban and Twigg, 2008; Wold et al., 2005; Wold et al., 2012). In this special issue of Life Sciences, we present a collection of mini-reviews and original research articles by leading experts in the field focused on diabetic cardiac dysfunction.
机译:糖尿病是一种复杂的,令人难以理解的疾病,其达到全世界的疫情水平,影响了多个器官系统。基于2011年的统计数据,美国近2600万人是糖尿病,额外7000万分为糖尿病患者(CDC糖尿病)2011)。这种糖尿病率的疫情率没有指示减少;相反,有证据表明,糖尿病是在年轻的兴起,与大约1 400青少年新诊断为糖尿病。无可否认糖尿病和心脏功能障碍之间的联系,糖尿病心肌病是持续的糖尿病的一个众所周知的后果(卡姆莱什沙,2007; Witteles和福勒,2008; Miki等,2012; Murarka和Movahed,2010) 。近70%的糖尿病相关死亡与心脏病有关,糖尿病患者由于心脏病而遭受两倍至四倍的死亡率,而不是心脏病而不是非糖尿病患者(CDC糖尿病actople,2011)。尽管有这些清醒的临床统计数据,但仍然对糖尿病如何影响心脏功能的影响仍然很少。然而,研究表明,糖尿病患者进行适当的心脏功能需要许多方面,包括心肌细胞代谢,促存活信号传导和钙处理产生不利影响,而且也诱导血管和心脏纤维化(卡姆莱什沙,2007;哥打等,2011; Law等。,2012;禁令和Twigg,2008; Wold等,2005; Wold等,2012)。在这一特别的生命科学问题中,我们通过专注于糖尿病心脏功能障碍的领域的专家提供了一系列迷你评论和原创研究文章。

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  • 来源
    《Life sciences》 |2013年第11期|共2页
  • 作者单位

    Louisiana State University Health Sciences Center Department of Physiology MEB 7205 1901 Perdido;

    Louisiana State University Health Sciences Center Department of Physiology MEB 7205 1901 Perdido;

    Louisiana State University Health Sciences Center Department of Physiology MEB 7205 1901 Perdido;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
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