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首页> 外文期刊>Life sciences >S100B: Role in cardiac remodeling and function following myocardial infarction in diabetes
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S100B: Role in cardiac remodeling and function following myocardial infarction in diabetes

机译：S100B：在心肌梗死糖尿病心肌梗死后的作用

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摘要

Aim: S100B plays a role in cardiac remodeling following myocardial infarction (MI) and in diabetic vascular complications but not examined in diabetic myocardium. We thus examined the effects of targeted deletion of S100B gene on post-MI hearts. Main methods: Coronary artery ligation or sham was performed 15 weeks after streptozotocin (STZ) or vehicle injection in wild-type (WT) and S100B knockout (BKO) mice. Left ventricular (LV) structural and functional remodeling was studied 35 days after induction of MI. Key findings: In diabetes, post-MI remodeling exhibited an attenuated increase in LV mass, dilation, and myocyte hypertrophy in association with increased apoptosis and fibrosis and reduced matrix metalloproteinase-2 (MMP-2) activity. Despite reduced LV dilation, impairment of cardiac function was similar to non-diabetic controls. Both diabetes and MI alone induced myocardial S100B and its canonical receptor for advanced glycation end product (RAGE) expression. By contrast, in post-MI diabetic myocardium, S100B expression was attenuated. Diabetic BKO, following MI demonstrated increased ventricular dilation compared to WT, in association with greater impairment of cardiac function, GLUT4 expression and systemic AGE levels. Significance: These data suggest that S100B expression may serve to modulate cardiac metabolism and adverse consequences of AGE in diabetic post-MI remodeling and function. ? 2012 Elsevier Inc.
机译：目的：S100B起着心脏重塑心肌梗死（MI）和糖尿病血管并发症，但在糖尿病心肌没有审查的作用。因此，我们检查了心肌梗死后心脏S100B基因靶向缺失的影响。主要的方法：冠状动脉结扎或假是在野生型（WT）链脲霉素（STZ）或载体注射后进行15周和S100B敲除（BKO）小鼠。左心室（LV）的结构和功能重塑被MI诱导35天后研究。主要发现：在糖尿病中，MI后重塑表现出与增加的细胞凋亡和纤维化关联在LV质量，膨胀，和肌细胞肥大减毒增加和减少的基质金属蛋白酶-2（MMP-2）的活性。尽管减少左心室扩张，心脏功能受损类似于非糖尿病对照。糖尿病和心肌梗死单独诱导的心肌S100B及其糖化终产物（RAGE）表达规范的受体。相反，在MI后糖尿病心肌，S100B表达减弱。糖尿病BKO，MI后证实相比增长心室扩张到WT，在伴随心功能，GLUT4表达和全身AGE水平的更大的损害。意义：这些数据表明，S100B表达可能起到调节心脏代谢和AGE在糖尿病心梗后重塑和功能的不良后果。还是2012年Elsevier Inc.

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  • 来源
    《Life sciences》 |2013年第11期|共9页
  • 作者

    MohammadzadehF.; DesjardinsJ.-F.; TsoporisJ.N.; ProteauG.; Leong-PoiH.; ParkerT.G.;

  • 作者单位

    Department of Medicine University of Toronto St. Michael's Hospital 30 Bond Street Bond Wing;

    Department of Medicine University of Toronto St. Michael's Hospital 30 Bond Street Bond Wing;

    Department of Medicine University of Toronto St. Michael's Hospital 30 Bond Street Bond Wing;

    Department of Medicine University of Toronto St. Michael's Hospital 30 Bond Street Bond Wing;

    Department of Medicine University of Toronto St. Michael's Hospital 30 Bond Street Bond Wing;

    Department of Medicine University of Toronto St. Michael's Hospital 30 Bond Street Bond Wing;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    Diabetes mellitus; Myocardial infarction; Remodeling; S100B;

    机译：糖尿病;心肌梗死;重塑;S100B;

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