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Antiviral marine natural products

机译：抗病毒海洋天然产物

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Limitations in our current antiviral treatment options and the continuing emergence of new pathogenic viruses have contributed to a growing need for new and effective chemotherapeutic agents to treat viral diseases. The marine environment provides a rich source of chemical diversity for the screening and identification of new compounds with desirable antiviral properties. Many of the new and structurally distinct metabolites that have been found in marine algae, invertebrate animals, and microorganisms have pronounced biological activities. Antiviral testing has revealed numerous compounds from structural classes including terpenoids, steroids, fatty acid derivatives, alkaloids, and peptides that potently inhibit both RNA and DNA viruses. Much of the recent antiviral research has focused on the human immunodeficiency virus (HIV) and the enzymes specific to this virus. Regardless of the specific assay system or screening approach that has been employed, a large number of structurally unique antiviral compounds from a broad taxonomic distribution of marine organisms have been identified. It is clear that marine natural products constitute a valuable chemical resource for the discovery of lead compounds that may aid in the development of new antiviral therapies.
机译：我们当前抗病毒治疗方案的局限性以及新的病原性病毒的不断出现，导致对治疗病毒性疾病的新型有效化疗药物的需求日益增长。海洋环境为筛选和鉴定具有理想抗病毒特性的新化合物提供了丰富的化学多样性资源。在海藻，无脊椎动物和微生物中发现的许多新的和结构上不同的代谢物具有明显的生物活性。抗病毒测试已揭示出许多结构类别的化合物，包括类萜，类固醇，脂肪酸衍生物，生物碱和能有效抑制RNA和DNA病毒的肽。最近的许多抗病毒研究都集中在人类免疫缺陷病毒（HIV）和对该病毒特有的酶上。无论采用了哪种特定的测定系统或筛选方法，都已经鉴定出了来自海洋生物的广泛分类学分布的大量结构独特的抗病毒化合物。显然，海洋天然产物构成了发现铅化合物的宝贵化学资源，这些铅化合物可能有助于开发新的抗病毒疗法。

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