...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Tissue modeling schemes in low energy breast brachytherapy.
【24h】

Tissue modeling schemes in low energy breast brachytherapy.

机译：低能乳房近距离放射治疗中的组织建模方案。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Breast tissue is heterogeneous and is mainly composed of glandular (G) and adipose (A) tissues. The proportion of G versus A varies considerably among the population. The absorbed dose distributions in accelerated partial breast irradiation therapy with low energy photon brachytherapy sources are very sensitive to tissue heterogeneities. Current clinical algorithms use the recommendations of the AAPM TG43 report which approximates the human tissues by unit density water. The aim of this study is to investigate various breast tissue modeling schemes for low energy brachytherapy. A special case of breast permanent seed implant is considered here. Six modeling schemes are considered. Uniform and non-uniform water breast (UWB and NUWB) consider the density but neglect the effect of the composition of tissues. The uniform and the non-uniform G/A breast (UGAB and NUGAB) as well the age-dependent breast (ADB) models consider the effect of the composition. The segmented breast tissue (SBT) method uses a density threshold to distinguish between G and A tissues. The PTV D(90) metric is used for the analysis and is based on the dose to water (D(90(w,m))). D(90(m,m)) is also reported for comparison to D(90(w,m)). The two-month post-implant D(90(w,m)) averaged over 38 patients is smaller in NUWB than in UWB by about 4.6% on average (ranging from 5% to 13%). Large average differences of G/A breast models with TG43 (17% and 26% in UGAB and NUGAB, respectively) show that the effect of the chemical composition dominates the effect of the density on dose distributions. D(90(w,m)) is 12% larger in SBT than in TG43 when averaged. These differences can be as low as 4% or as high as 20% when the individual patients are considered. The high sensitivity of dosimetry on the modeling scheme argues in favor of an agreement on a standard tissue modeling approach to be used in low energy breast brachytherapy. SBT appears to generate the most geometrically reliable breast tissue models in this report.
机译：乳房组织是异质的，主要由腺体（g）和脂肪（a）组织组成。 G与A的比例在人口中变化很大。具有低能光子近距离放射治疗源的加速部分乳房辐射治疗中的吸收剂量分布对组织异质性非常敏感。目前的临床算法利用AAPM TG43报告的建议，其通过单位密度水近似于人体组织。本研究的目的是研究各种乳房组织建模方案，用于低能量近距离放射治疗。这里考虑了一个特殊的乳房永久性种子植入物。考虑了六种建模方案。均匀和非均匀的水乳房（UWB和NuWB）考虑密度但忽略组织组成的效果。均匀和不均匀的G / A乳房（UgAb和Nugab）以及年龄依赖性乳房（ADB）模型考虑了组合物的作用。分段乳房组织（SBT）方法使用密度阈值来区分G和组织。 PTV D（90）度量用于分析，并基于水的剂量（D（90（w，m）））。还报告了D（90（m））以比较d（90（w，m））。对于38例患者的平均为期两月的植入物D（90（W，M）），NuWB的较小比UWB更小，平均约4.6％（范围为5％至13％）。 G / A分别具有TG43的乳房模型的平均平均差异（分别在ugab和南巴比中的17％和26％）表明化学成分的效果主导了密度对剂量分布的影响。当平均时，D（90（w，m））在SBT中比在TG43中更大12％。当考虑各个患者时，这些差异可以低至4％或高达20％。剂量法对建模方案的高灵敏度赞成关于在低能量乳房近距离放射治疗中使用的标准组织建模方法的协议。 SBT似乎在本报告中产生最多的几何可靠乳房组织模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号