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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Acute toxicity studies and determination of median lethal dose
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Acute toxicity studies and determination of median lethal dose

机译：急性毒性研究和中值致死剂量的确定

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Whenever an investigator administers a chemical substance to a biological system, different types of interactions can occur and a series of dose-related responses result. In most cases these responses are desired and useful, but there are a number of other effects which are not advantageous. These may or may not be harmful to the patients. The types of toxicity tests which are routinely performed by pharmaceutical manufactures in the investigation of a new drug involve acute, sub-acute and chronic toxicity. Acute toxicity is involved in estimation of LD50 (the dose which has proved to be lethal (causing death) to 50% of the tested group of animals).Determination of acute oral toxicity is usually an initial screening step in the assessment and evaluation of the toxic characteristics of all compounds. This article reviews the methods so far utilized for the determination of median lethal dose; (LD50) and the new changes which could be made. This has to go through the entire process of validation with different categories of substances before its final acceptance by regulatory bodies.
机译：每当研究人员将化学物质施用于生物系统时，就会发生不同类型的相互作用，并导致一系列剂量相关的反应。在大多数情况下，这些响应是理想且有用的，但是还有许多其他不利的影响。这些可能或可能不会对患者有害。药物制造商通常在研究新药时进行的毒性测试类型涉及急性，亚急性和慢性毒性。急性毒性涉及LD50的估计（经证实对50％的动物试验组具有致死性（致死）的剂量）急性口服毒性的测定通常是评估和评估LD50的初步筛选步骤。所有化合物的毒性特征。本文回顾了迄今为止用于确定中值致死剂量的方法。 （LD50）和可能进行的新更改。在被监管机构最终接受之前，这必须经过对不同类别物质的验证的整个过程。

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