...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current sports medicine reports. >Chronic traumatic encephalopathy.
【24h】

Chronic traumatic encephalopathy.

机译：慢性外伤性脑病。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sports-related concussion has gained increased prominence, in part due to media coverage of several well-known athletes who have died from consequences of chronic traumatic encephalopathy (CTE). CTE was first described by Martland in 1928 as a syndrome seen in boxers who had experienced significant head trauma from repeated blows. The classic symptoms of impaired cognition, mood, behavior, and motor skills also have been reported in professional football players, and in 2005, the histopathological findings of CTE were first reported in a former National Football League (NFL) player. These finding were similar to Alzheimer's disease in some ways but differed in critical areas such as a predominance of tau protein deposition over amyloid. The pathophysiology is still unknown but involves a history of repeated concussive and subconcussive blows and then a lag period before CTE symptoms become evident. The involvement of excitotoxic amino acids and abnormal microglial activation remain speculative. Early identification and prevention of this disease by reducing repeated blows to the head has become a critical focus of current research.
机译：与体育有关的脑震荡日益突出，部分原因是媒体报道了几位因慢性创伤性脑病（CTE）的后果而死亡的著名运动员。 Martland于1928年首次将CTE描述为一种拳击手综合征，这种拳击手因反复打击而遭受了严重的头部外伤。在职业足球运动员中，也已经报告了认知，情绪，行为和运动技能受损的典型症状。2005年，CTE的组织病理学发现首次在前国家橄榄球联盟（NFL）运动员中报告。这些发现在某些方面类似于阿尔茨海默氏病，但在关键领域有所不同，例如tau蛋白沉积超过淀粉样蛋白。病理生理学仍是未知的，但是涉及反复的脑震荡和脑震荡打击的病史，然后是CTE症状变得明显之前的滞后时期。兴奋性毒性氨基酸的参与和异常的小胶质细胞激活仍然是推测。通过减少对头部的反复打击，及早发现和预防这种疾病已成为当前研究的重点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号