Accelerating two-dimensional nuclear magnetic resonance correlation spectroscopy via selective coherence transfer

Ye Qimiao; Chen Lin; Qiu Wenqi; Lin Liangjie; Sun Huijun; Cai Shuhui; Wei Zhiliang; Chen Zhong

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Accelerating two-dimensional nuclear magnetic resonance correlation spectroscopy via selective coherence transfer

机译：通过选择性相干转移加速二维核磁共振相关光谱分析

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Nuclear magnetic resonance (NMR) spectroscopy serves as an important tool for both qualitative and quantitative analyses of various systems in chemistry, biology, and medicine. However, applications of one- dimensional H-1 NMR are often restrained by the presence of severe overlap among different resonances. The advent of two-dimensional (2D) H-1 NMR constitutes a promising alternative by extending the crowded resonances into a plane and thereby alleviating the spectral congestions. However, the enhanced ability in discriminating resonances is achieved at the cost of extended experimental duration due to necessity of various scans with progressive delays to construct the indirect dimension. Therefore, in this study, we propose a selective coherence transfer (SECOT) method to accelerate acquisitions of 2D correlation spectroscopy by converting chemical shifts into spatial positions within the effective sample length and then performing an echo planar spectroscopic imaging module to record the spatial and spectral information, which generates 2D correlation spectrum after 2D Fourier transformation. The feasibility and effectiveness of SECOT have been verified by a set of experiments under both homogeneous and inhomogeneous magnetic fields. Moreover, evaluations of SECOT for quantitative analyses are carried out on samples with a series of different concentrations. Based on these experimental results, the SECOT may open important perspectives for fast, accurate, and stable investigations of various chemical systems both qualitatively and quantitatively. Published by AIP Publishing.

机译：核磁共振（NMR）光谱用作化学，生物学和医学中各种系统的定性和定量分析的重要工具。然而，一维H-1 NMR的应用通常通过不同共振之间的严重重叠存在而受到抑制。通过将拥挤的共振延伸到平面中，二维（2D）H-1 NMR的出现构成了有希望的替代方案，从而减轻光谱血管。然而，由于各种扫描的必要性来构建间接尺寸，因此由于各种扫描的必要性，以延长实验持续时间的成本实现了鉴别谐振的增强能力。因此，在本研究中，我们提出了一种选择性相干转移（SELOT）方法，以通过将化学位移转换为有效采样长度内的空间位置，然后执行回声平面光谱成像模块来加速对2D相关光谱的采集，以记录空间和光谱在2D傅里叶变换后产生2D相关谱的信息。通过在均匀和不均匀的磁场下通过一组实验验证了分子的可行性和有效性。此外，对定量分析的分子的评估在具有一系列不同浓度的样品上进行。基于这些实验结果，分子可以在定性和定量上开放用于快速，准确，稳定地研究各种化学系统的重要视角。通过AIP发布发布。

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来源
《The Journal of Chemical Physics》 |2017年第1期|共10页
作者
Ye Qimiao; Chen Lin; Qiu Wenqi; Lin Liangjie; Sun Huijun; Cai Shuhui; Wei Zhiliang; Chen Zhong;
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Xiamen Univ Dept Elect Sci Fujian Prov Key Lab Plasma &

Magnet Resonance State Key Lab Phys Chem Solid Surfaces Xiamen Peoples R China;

Xiamen Univ Dept Elect Sci Fujian Prov Key Lab Plasma &

Magnet Resonance State Key Lab Phys Chem Solid Surfaces Xiamen Peoples R China;

Xiamen Univ Dept Elect Sci Fujian Prov Key Lab Plasma &

Magnet Resonance State Key Lab Phys Chem Solid Surfaces Xiamen Peoples R China;

Xiamen Univ Dept Elect Sci Fujian Prov Key Lab Plasma &

Magnet Resonance State Key Lab Phys Chem Solid Surfaces Xiamen Peoples R China;

Xiamen Univ Dept Elect Sci Fujian Prov Key Lab Plasma &

Magnet Resonance State Key Lab Phys Chem Solid Surfaces Xiamen Peoples R China;

Xiamen Univ Dept Elect Sci Fujian Prov Key Lab Plasma &

Magnet Resonance State Key Lab Phys Chem Solid Surfaces Xiamen Peoples R China;

Xiamen Univ Dept Elect Sci Fujian Prov Key Lab Plasma &

Magnet Resonance State Key Lab Phys Chem Solid Surfaces Xiamen Peoples R China;

Xiamen Univ Dept Elect Sci Fujian Prov Key Lab Plasma &

Magnet Resonance State Key Lab Phys Chem Solid Surfaces Xiamen Peoples R China;

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正文语种 eng
中图分类物理化学（理论化学）、化学物理学;
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Accelerating two-dimensional nuclear magnetic resonance correlation spectroscopy via selective coherence transfer

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