Rotavirus vaccines and intussusception risk

Julie E. Bines

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Rotavirus vaccines and intussusception risk

机译：轮状病毒疫苗和肠套叠风险

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The association between Rotashield and the development of intussusception has presented a major challenge to the development of rotavirus vaccines. Intussusception risk is greatest in the first 3 to 14 days following the receipt of the first dose of Rotashield in infants older than 3 months of age. Although there continues to be debate surrounding the exact quantitation of risk of intussusception, it is accepted as a rare adverse event. The development of alternate rotavirus vaccines and emerging manufacturers in developing countries has renewed optimism for the reduction of the global burden of rotavirus disease.

机译：Rotashield和肠套叠的发展之间的关联已向轮状病毒疫苗的发展提出了重大挑战。在3个月以上的婴儿中，在接受第一剂Rotashield后的头3到14天内，肠套叠风险最高。尽管围绕肠套叠风险的确切定量方法仍存在争议，但它被认为是罕见的不良事件。轮状病毒替代疫苗的开发和发展中国家的新兴制造商对减少轮状病毒疾病的全球负担重新表示了乐观。

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《Current opinion in gastroenterology》 |2005年第1期|共6页
作者
Julie E. Bines;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
intussusception; rotavirus vaccine; gastroenteritis;

机译：肠套叠;轮状病毒疫苗;肠胃炎;

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1. A Hexavalent Human Rotavirus-Bovine Rotavirus (UK) Reassortant Vaccine Designed for Use in Developing Countries and Delivered in a Schedule with the Potential to Eliminate the Risk of Intussusception. [J] . Kapikian AZ, Simonsen L, Vesikari T, The Journal of Infectious Diseases . 2005,第Suppla1期

机译：专为发展中国家设计的六价人类轮状病毒-牛轮状病毒（英国）重配疫苗有计划交付，有望消除肠套叠的风险。
2. Assessment of risk of intussusception after pilot rollout of rotavirus vaccine in the Indian public health system [J] . Bhandari Nita, Antony Kalpana, Balraj Vinohar, Vaccine . 2020,第33期

机译：印度公共卫生系统轮状病毒疫苗试点推出后的肠套瘤风险评估
3. A case-control study of risk factors for intussusception among infants in eastern France after the introduction of the rotavirus vaccine [J] . Vaccine . 2019,第32期

机译：旋转病毒疫苗后婴幼儿婴幼儿肠套危险因素的病例对照研究
4. The effect of vaccination of gilts with a pre-farrow rotavirus RNA particle vaccine following pre-breeding natural planned exposure on piglet growth and viral shedding [C] . Annual^Meeting of The American^Association^of^Swine^Veterinarians. . 2019

机译：在仔猪生长和病毒脱落后，用预育种自然计划暴露后，GILTTS接种胃肠术治疗胃肠前rotavirus RNA颗粒疫苗的影响
5. Studies of human rotavirus candidate non-replicating vaccines and innate immunity in a gnotobiotic pig model of human rotavirus disease . [D] . Gonzalez, Ana Maria. 2007

机译：人轮状病毒候选非复制疫苗和人免疫原性免疫的研究
6. Retrospective multicenter matched case–control study on the risk factors for intussusception in infants less than 1 year of age with a special focus on rotavirus vaccines – the German Intussusception Study [O] . Doris Oberle, Marcus Hoffelner, Jutta Pavel, 2020

机译：回顾性多中心匹配案例对照研究婴儿在婴儿肠套肠套危险因素较少特别关注轮状病毒疫苗 - 德国肠套疫苗研究
7. A Hexavalent Human Rotavirus–Bovine Rotavirus (UK) Reassortant Vaccine Designed for Use in Developing Countries and Delivered in a Schedule with the Potential to Eliminate the Risk of Intussusception [O] . Albert Z. Kapikian, Lone Simonsen, Timo Vesikari, 2005

机译：六价人体轮状病毒 - 牛旋转病毒（英国）重新排列疫苗，专为发展中国家使用，并在一个时间表中交付，潜力消除肠套化的风险
8. Monitoring for Intussusception After Two Rotavirus Vaccines by the PRISM Program: Mini-Sentinel CBER Surveillance Protocol. [R] . Yih, K., Lieu, T., Kulldorff, M., 2011

机译：通过pRIsm计划监测两种轮状病毒疫苗后的肠套叠：mini-sentinel CBER监测协议。

Rotavirus vaccines and intussusception risk

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