• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in gastroenterology >Chronic pancreatitis
【24h】

Chronic pancreatitis

机译：慢性胰腺炎

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

An increasing number of novel mutations are associated with chronic pancreatitis. Some cause a high-penetrance, autosomal dominant type of clinical picture (eg, mutations at codons 29 and 122 of the cationic trypsinogen gene), whereas others have a low penetrance or are frequent in the general population (eg, mutations in Kazal type 1 [SPINK1] and in codons 16, 22, and 23 of the cationic trypsinogen gene) and act as disease modifiers. The results of recent studies indicate that smoking adversely affects the course and complications of chronic pancreatitis (more frequent and faster rate of calcification and higher risk of development of pancreatic cancer). Thus, regardless of the cause of chronic pancreatis, patients with this condition should not smoke. Using current diagnostic criteria, the accuracy of endoscopic ultrasound for the diagnosis of chronic pancreatitis is not good. For example, 39% of dyspeptic persons without any other evidence of chronic pancreatitis fulfilled the endoscopic ultrasound criteria for chronic pancreatitis. Diabetes frequently occurs in chronic pancreatitis, but it is not prevented or increased by pancreatic surgery. Islet cell autotransplantation holds promise for the prevention of diabetes in patients requiring total pancreatectomy if the pancreas is not extensively fibrotic. Splenic vein occlusion is present in 7% of patients undergoing surgery for chronic pancreatitis, but fewer tnan one fifth of these patients have variceal bleeding before or after Surgery
机译：越来越多的新突变与慢性胰腺炎有关。一些引起临床表现的高渗透性，常染色体显性类型（例如，阳离子胰蛋白酶原基因的第29和122位密码子的突变），而另一些则具有低渗透性或在普通人群中很常见（例如，Kazal 1型的突变）。 [SPINK1]以及阳离子胰蛋白酶原基因的16、22和23号密码子，并起疾病改良剂的作用。最近的研究结果表明，吸烟会对慢性胰腺炎的病程和并发症产生不利影响（更频繁，更快的钙化速率以及更高的胰腺癌发生风险）。因此，无论慢性胰腺炎的病因如何，患有这种疾病的患者都不应吸烟。使用当前的诊断标准，内镜超声诊断慢性胰腺炎的准确性并不高。例如，没有其他任何慢性胰腺炎证据的消化不良者中有39％符合慢性胰腺炎的内镜超声检查标准。糖尿病常发生于慢性胰腺炎中，但不能通过胰腺手术预防或增加。如果胰脏未广泛纤维化，胰岛细胞自体移植有望在需要全胰切除术的患者中预防糖尿病。 7％的慢性胰腺炎手术患者存在脾静脉闭塞，但这些患者中有五分之一的患者术前或术后有静脉曲张破裂出血

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号